PMID- 7886013
OWN - NLM
STAT- MEDLINE
DCOM- 19950412
LR  - 20191101
IS  - 0172-8113 (Print)
IS  - 0172-8113 (Linking)
VI  - 16
IP  - 1
DP  - 1995 Jan
TI  - [Cytogenetics and molecular studies confirm the histopathologic diagnosis of 
      chronic myeloproliferative diseases].
PG  - 41-5
AB  - The histopathological classification of chronic myeloproliferative disorders can 
      be supported by applying cytogenetics and molecular genetics to the analysis of 
      bone marrow or blood cells, as demonstrated in 253 cases evaluated. The 
      Philadelphia translocation (9;22) is the most important genetic parameter, being 
      specific for chronic myeloid leukemia. Conventional methods for the detection of 
      the t(9;22) are karyotyping and Southern blot analysis of the bcr gene. The newly 
      established technique of fluorescence in situ hybridization (FISH) allows 
      visualization of bcr-abl fusion even in non dividing cells. Molecular 
      cytogenetics for t(9;22) yield results that are rapid and reliable as well as 
      easily quantifiable.
FAU - Werner, M
AU  - Werner M
AD  - Pathologisches Institut, Medizinische Hochschule Hannover.
FAU - Nolte, M
AU  - Nolte M
FAU - Ewing, M
AU  - Ewing M
FAU - Kaloutsi, V
AU  - Kaloutsi V
FAU - Kausche, F
AU  - Kausche F
FAU - Georgii, A
AU  - Georgii A
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Zytogenetik und molekulare Untersuchungen sichern die histopathologischen 
      Diagnosen von chronischen myeloproliferativen Erkrankungen ab.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
RN  - EC 2.7.11.1 (BCR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-bcr)
SB  - IM
MH  - Biopsy
MH  - Blotting, Southern
MH  - Bone Marrow/pathology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 22
MH  - Chromosomes, Human, Pair 9
MH  - Diagnosis, Differential
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Gene Rearrangement
MH  - Genes, abl/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/pathology
MH  - Myeloproliferative Disorders/*genetics/pathology
MH  - Philadelphia Chromosome
MH  - Polycythemia Vera/genetics/pathology
MH  - Primary Myelofibrosis/genetics/pathology
MH  - *Protein-Tyrosine Kinases
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-bcr
MH  - Thrombocythemia, Essential/genetics/pathology
MH  - Translocation, Genetic/genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/s002920050074 [doi]
PST - ppublish
SO  - Pathologe. 1995 Jan;16(1):41-5. doi: 10.1007/s002920050074.