PMID- 7886404
OWN - NLM
STAT- MEDLINE
DCOM- 19950413
LR  - 20190814
IS  - 0036-5521 (Print)
IS  - 0036-5521 (Linking)
VI  - 29
IP  - 12
DP  - 1994 Dec
TI  - Endoscopic ultrasonographic evaluation of gastric ulcer healing on treatment with 
      proton pump inhibitors versus H2-receptor antagonists.
PG  - 1140-4
AB  - BACKGROUND: It has been reported that time to peptic ulcer healing is shorter 
      with proton pump inhibitors (PPI) than with H2-receptor antagonists (H2-RA). This 
      study was designed to examine the difference in the healing process between 
      gastric ulcers treated with PPI and those treated with H2-RA. METHODS: The 
      healing of deep gastric ulcers treated with PPI (n = 11) or H2-RA (n = 13) was 
      evaluated with endoscopic ultrasonography (EUS). Every 2 weeks during treatment 
      EUS variables such as the width and the depth of the ulcer crater, the thickness 
      and size of the low echoic area of the ulcer base, and the distance of the 
      disrupted muscularis propria were measured. The contraction rates of EUS 
      variables, the ratios of the contraction rate of the depth to that of the width 
      of the ulcer crater (D/W ratio) and the contraction rate of the distance of the 
      disrupted muscularis propria layer to that of the width of the ulcer crater (Dm/W 
      ratio) were calculated. RESULTS: Only at week 2 were the D/W ratio and Dm/W ratio 
      significantly higher in the group receiving PPI (D/W ratio, 1.79 +/- 0.701; Dm/W 
      ratio, 0.938 +/- 0.207) than in the group receiving H2-RA (D/W ratio, 1.10 +/- 
      0.559; Dm/W ratio, 0.641 +/- 0.166). CONCLUSION: This study demonstrated that PPI 
      therapy is associated with more rapid and stronger healing than obtained with 
      H2-RA during the early treatment period.
FAU - Tanaka, M
AU  - Tanaka M
AD  - Third Dept. of Internal Medicine, Faculty of Medicine, Kyushu University, 
      Fukuoka, Japan.
FAU - Maruoka, A
AU  - Maruoka A
FAU - Chijiiwa, Y
AU  - Chijiiwa Y
FAU - Tanaka, M
AU  - Tanaka M
FAU - Nawata, H
AU  - Nawata H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Piperidines)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 5QZO15J2Z8 (Famotidine)
RN  - KG60484QX9 (Omeprazole)
RN  - P41PML4GHR (Nizatidine)
RN  - ZUP3LSD0DO (roxatidine acetate)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Adult
MH  - Aged
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Famotidine/therapeutic use
MH  - Female
MH  - Gastroscopy
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - Lansoprazole
MH  - Male
MH  - Middle Aged
MH  - Nizatidine/therapeutic use
MH  - Omeprazole/analogs & derivatives/therapeutic use
MH  - Piperidines/therapeutic use
MH  - *Proton Pump Inhibitors
MH  - *Stomach Ulcer/diagnostic imaging/drug therapy/pathology
MH  - Ultrasonography, Interventional
MH  - Wound Healing/*drug effects
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.3109/00365529409094901 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 1994 Dec;29(12):1140-4. doi: 10.3109/00365529409094901.