PMID- 7888598
OWN - NLM
STAT- MEDLINE
DCOM- 19950418
LR  - 20191023
IS  - 0142-2782 (Print)
IS  - 0142-2782 (Linking)
VI  - 15
IP  - 8
DP  - 1994 Nov
TI  - The effect of different routes of administration on the metabolism of morphine: 
      the disposition of morphine and its metabolites after topical application.
PG  - 665-78
AB  - The disposition of morphine (MOR) and its metabolites in the rabbit was measured 
      after topical administration of its hydrochloride salt (MOR.HCl), and their time 
      course was compared with those after intravenous and oral administration. The 
      area under the plasma concentration-time curve (AUC) ratio of metabolites/MOR 
      after the topical application of MOR.HCl was similar to that after intravenous 
      injection, but differed from that after oral administration. Pharmacokinetic 
      parameters of the disposition of MOR and its metabolites were obtained by a 
      general curve fitting of the time course of plasma concentrations of these 
      compounds after intravenous injection of MOR.HCl and its metabolites, 
      respectively. On the other hand, the time courses of plasma concentrations of the 
      metabolites after intravenous, oral, and topical administration of MOR.HCl were 
      simulated using a simple compartment model without consideration of enterohepatic 
      circulation and the pharmacokinetic parameters obtained as above. The resulting 
      curves of the metabolites agreed well with the observed values except for those 
      after oral administration. These results suggest that no first-pass metabolism of 
      MOR.HCl occurs after percutaneous administration, and that topical administration 
      of this salt is more advantageous than oral administration in terms of 
      bioavailability.
FAU - Matsuzawa, T
AU  - Matsuzawa T
AD  - Research Institute of TTS Technology Co., Ltd., Saitama, Japan.
FAU - Wada, Y
AU  - Wada Y
FAU - Shimoyama, M
AU  - Shimoyama M
FAU - Nakajima, K
AU  - Nakajima K
FAU - Seki, T
AU  - Seki T
FAU - Sugibayashi, K
AU  - Sugibayashi K
FAU - Morimoto, Y
AU  - Morimoto Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Biopharm Drug Dispos
JT  - Biopharmaceutics & drug disposition
JID - 7911226
RN  - 0 (Glucuronates)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Administration, Oral
MH  - Administration, Topical
MH  - Animals
MH  - Biological Availability
MH  - Glucuronates/blood/urine
MH  - Injections, Intravenous
MH  - Liver/metabolism
MH  - Male
MH  - Morphine/administration & dosage/blood/*pharmacokinetics/urine
MH  - Rabbits
MH  - Regression Analysis
MH  - Tissue Distribution
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1002/bdd.2510150805 [doi]
PST - ppublish
SO  - Biopharm Drug Dispos. 1994 Nov;15(8):665-78. doi: 10.1002/bdd.2510150805.