PMID- 7889502
OWN - NLM
STAT- MEDLINE
DCOM- 19950420
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 79
IP  - 2
DP  - 1995 Feb
TI  - Chromosomal instability in multiple endocrine neoplasia type 1. Cytogenetic 
      evaluation with DEB test.
PG  - 123-6
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant condition 
      with high penetrance and variable expressivity, in which tumors or hyperplasia 
      occur in two or more endocrine organs. Some authors have investigated chromosomal 
      instability in MEN 1 and MEN 2; the results are controversial. Chromosome 
      analyses were performed on lymphocytes from seven patients with MEN 1, four 
      healthy first-degree relatives (three of whom were children), six phenotypically 
      normal volunteers, and three patients with Fanconi's anemia. To evaluate 
      chromosomal instability we analyzed phytohemagglutinin-stimulated lymphocyte 
      cultures with and without diepoxibutane. We observed an increase in the frequency 
      of spontaneous chromosomal alterations in four patients. After the DEB test we 
      found an increase in chromatid breakages, gaps, and exchange figures. These 
      findings support the inclusion of the MEN 1 syndrome among the disorders with 
      "chromosomal instability."
FAU - Tomassetti, P
AU  - Tomassetti P
AD  - Medical Clinic, University of Bologna, Italy.
FAU - Cometa, G
AU  - Cometa G
FAU - Del Vecchio, E
AU  - Del Vecchio E
FAU - Baserga, M
AU  - Baserga M
FAU - Faccioli, P
AU  - Faccioli P
FAU - Bosoni, D
AU  - Bosoni D
FAU - Paolucci, G
AU  - Paolucci G
FAU - Barbara, L
AU  - Barbara L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Alkylating Agents)
RN  - 0 (Epoxy Compounds)
RN  - 60OB65YNAB (diepoxybutane)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alkylating Agents
MH  - Cells, Cultured
MH  - *Chromosome Aberrations
MH  - Epoxy Compounds
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 0165-4608(95)98126-J [pii]
AID - 10.1016/0165-4608(95)98126-j [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1995 Feb;79(2):123-6. doi: 10.1016/0165-4608(95)98126-j.