PMID- 7889516 OWN - NLM STAT- MEDLINE DCOM- 19950420 LR - 20190816 IS - 0165-4608 (Print) IS - 0165-4608 (Linking) VI - 79 IP - 2 DP - 1995 Feb TI - Translocation (1;14)(p34;q11) and trisomy 8 in a T-cell acute lymphoblastic leukemia patient. PG - 177-81 AB - A case of T-cell acute lymphoblastic leukemia (T-ALL) in a 25-year-old man cytogenetically characterized by a t(1;14)(p34;q11) and trisomy 8 is reported. These chromosome abnormalities were observed in 82% of the analyzed metaphases. Fluorescence in situ hybridization (FISH) with a probe for the centromere of chromosome 8 was used to correlate cellular morphology in bone marrow (BM) cells with May-Grunwald-Giemsa smears and the cytogenetic alterations. By FISH analysis, trisomy 8 (and presumably the associated t[1;14]) was demonstrated only in lymphoid blast cells but not in the rest of the cells belonging to other hematopoietic lineages. FAU - Martin-Henao, G A AU - Martin-Henao GA AD - Departamento de Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. FAU - Sureda, A AU - Sureda A LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Cancer Genet Cytogenet JT - Cancer genetics and cytogenetics JID - 7909240 SB - IM MH - Adult MH - *Chromosomes, Human, Pair 1 MH - *Chromosomes, Human, Pair 14 MH - *Chromosomes, Human, Pair 8 MH - Humans MH - Karyotyping MH - Leukemia-Lymphoma, Adult T-Cell/*genetics MH - Male MH - *Translocation, Genetic MH - Trisomy/*genetics EDAT- 1995/02/01 00:00 MHDA- 1995/02/01 00:01 CRDT- 1995/02/01 00:00 PHST- 1995/02/01 00:00 [pubmed] PHST- 1995/02/01 00:01 [medline] PHST- 1995/02/01 00:00 [entrez] AID - 0165-4608(94)00054-F [pii] AID - 10.1016/0165-4608(94)00054-f [doi] PST - ppublish SO - Cancer Genet Cytogenet. 1995 Feb;79(2):177-81. doi: 10.1016/0165-4608(94)00054-f.