PMID- 7889806
OWN - NLM
STAT- MEDLINE
DCOM- 19950420
LR  - 20190904
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 36
IP  - 3
DP  - 1994 Dec
TI  - Behavioral and developmental effects of two 3,4-methylenedioxymethamphetamine 
      (MDMA) derivatives.
PG  - 161-6
AB  - The effects of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstacy') and two 
      structurally related compounds, 
      N-methyl-1-(3,4-methylenedioxyphenyl)-1-ethanamine (MDM1EA) and 
      N-methyl-1-(3,4-methylenedioxyphenyl)-3-butanamine (HMDMA) were examined in two 
      preparations: (i) a drug discrimination procedure in MDMA-trained rats and (ii) 
      the chicken embryo, for determination of the direct effects of these compounds on 
      the developing organism. The highest doses of MDM1EA and HMDMA partially 
      substituted for MDMA, whereas higher (30-60 mg/kg) doses of HMDMA evoked clonic 
      seizures in a separate group of rats. In chicken embryos MDMA had no effect on 
      body, brain or liver weight, while the highest dose of MDM1EA decreased body 
      weight and the 2 lowest doses of HMDMA increased body weight. All doses of HMDMA 
      decreased liver weight (expressed as % body weight) when compared with 
      contemporaneous water-treated controls. Taken together, the results of these 
      experiments suggest that structurally related compounds share some stimulus 
      properties with MDMA and may therefore share abuse liability. Furthermore, both 
      MDMA-related compounds produced adverse effects on the developing organism, 
      whereas MDMA did not.
FAU - Bronson, M E
AU  - Bronson ME
AD  - Department of Pharmacal Sciences, Auburn University, AL 36849-5503.
FAU - Barrios-Zambrano, L
AU  - Barrios-Zambrano L
FAU - Jiang, W
AU  - Jiang W
FAU - Clark, C R
AU  - Clark CR
FAU - DeRuiter, J
AU  - DeRuiter J
FAU - Newland, M C
AU  - Newland MC
LA  - eng
GR  - DA06637/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Designer Drugs)
RN  - 121734-64-3 (3,4-methylenedioxyphenyl-1-ethanamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 92279-87-3 (N-methyl-3,4-methylenedioxyphenylisobutylamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology/toxicity
MH  - Abnormalities, Drug-Induced/*etiology
MH  - Animals
MH  - Appetitive Behavior/drug effects
MH  - Arousal/*drug effects
MH  - Body Weight/drug effects
MH  - Brain/drug effects
MH  - Chick Embryo
MH  - Designer Drugs/*pharmacology/toxicity
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Liver/drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analogs & 
      derivatives/pharmacology/toxicity
MH  - Organ Size/drug effects
MH  - Rats
MH  - Structure-Activity Relationship
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 0376-8716(94)90141-4 [pii]
AID - 10.1016/0376-8716(94)90141-4 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 1994 Dec;36(3):161-6. doi: 10.1016/0376-8716(94)90141-4.