PMID- 789 OWN - NLM STAT- MEDLINE DCOM- 19760219 LR - 20211203 IS - 0036-553X (Print) IS - 0036-553X (Linking) VI - 15 IP - 4 DP - 1975 Nov TI - Allogeneic marrow transplantation for the treatment of leukaemia. A review. PG - 287-305 AB - 22 HL-A antigen and mixed leukocyte culture-matched sibling bone marrow transplants were attempted in patients with acute leukaemia (at the National Cancer Institute) to define the toxicities of four different immunosuppressive regimens, the complications associated with warrow engraftment and antileukaemic effect. 73% (16/22) were engrafted as indicated by a change to donor red blood cells (RBC) type, leukocyte, immunoglobulin allotype or by the speed of morrow repopulation and the occurrence of the Graft Versus Host Disease (GVHD). 12 of 16 (75%) successful engrafted patients developed GVHD. The current published results of clinical bone marrow transplantation from major centers has been reviewed and will be discussed in relationship to current clinical complications associated with bone marrow transplantation. FAU - Alvegard, T A AU - Alvegard TA FAU - Herzig, G P AU - Herzig GP FAU - Graw, R G Jr AU - Graw RG Jr LA - eng PT - Case Reports PT - Journal Article PL - Denmark TA - Scand J Haematol JT - Scandinavian journal of haematology JID - 0404507 RN - 0 (HLA Antigens) RN - 0 (Immunoglobulins) SB - IM MH - Adolescent MH - *Bone Marrow Cells MH - *Bone Marrow Transplantation MH - Evaluation Studies as Topic MH - Female MH - Graft vs Host Reaction MH - HLA Antigens MH - Histocompatibility Testing MH - Humans MH - Immunoglobulins MH - Immunosuppression Therapy MH - Leukemia/*therapy MH - Leukemia, Lymphoid/immunology/therapy MH - Leukemia, Monocytic, Acute/immunology/therapy MH - Leukemia, Myeloid, Acute/immunology/therapy MH - Lymphocyte Culture Test, Mixed MH - Male MH - Transplantation, Homologous EDAT- 1975/11/01 00:00 MHDA- 2001/03/28 10:01 CRDT- 1975/11/01 00:00 PHST- 1975/11/01 00:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1975/11/01 00:00 [entrez] AID - 10.1111/j.1600-0609.1975.tb01084.x [doi] PST - ppublish SO - Scand J Haematol. 1975 Nov;15(4):287-305. doi: 10.1111/j.1600-0609.1975.tb01084.x.