PMID- 7890171
OWN - NLM
STAT- MEDLINE
DCOM- 19950420
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 154
IP  - 2
DP  - 1995 Mar 10
TI  - Genomic organization and promoter sequence of a gene encoding a rat 
      liver-specific type-I transport protein.
PG  - 243-7
AB  - We report the isolation and characterization of a rat gene (designated TI-LTP) 
      encoding a liver-specific cell-surface glycoprotein that belongs to the type-I 
      transporter family. This gene, including 5' and 3' flanking domains, was cloned 
      from a rat lambda DASH genomic library and its nucleotide sequence was 
      determined. TI-LTP is a single-copy gene which spans over 6 kb, and contains nine 
      introns ranging in size from 90 bp to over 1.8 kb. Two transcription start points 
      were located using a nuclease S-1 protection assay. The TI-LTP promoter (pTI-LTP) 
      lacks a canonical TATA-box element, but does contain five TAGA elements. Several 
      putative transcription-factor-binding sites were identified in the pTI-LTP, 
      including activator protein 2 (AP-2) sites and a peroxisome proliferator response 
      element (PPRE).
FAU - Simonson, G D
AU  - Simonson GD
AD  - Department of Genetics and Cell Biology, University of Minnesota, St. Paul 55108, 
      USA.
FAU - Iwanij, V
AU  - Iwanij V
LA  - eng
SI  - GENBANK/L30107
GR  - DK43794/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Transcription Factor AP-2)
RN  - 0 (Transcription Factors)
SB  - IM
GS  - TI-LTP
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Biological Transport
MH  - Blotting, Southern
MH  - Carrier Proteins/*genetics
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/metabolism
MH  - Exons
MH  - Gene Expression Regulation
MH  - Introns
MH  - Liver/*chemistry/metabolism
MH  - Membrane Glycoproteins/genetics
MH  - Molecular Sequence Data
MH  - Operator Regions, Genetic
MH  - Organ Specificity
MH  - Promoter Regions, Genetic
MH  - Rats
MH  - Receptors, Cytoplasmic and Nuclear/metabolism
MH  - Restriction Mapping
MH  - Sequence Analysis, DNA
MH  - Transcription Factor AP-2
MH  - Transcription Factors/metabolism
EDAT- 1995/03/10 00:00
MHDA- 1995/03/10 00:01
CRDT- 1995/03/10 00:00
PHST- 1995/03/10 00:00 [pubmed]
PHST- 1995/03/10 00:01 [medline]
PHST- 1995/03/10 00:00 [entrez]
AID - 037811199400824C [pii]
AID - 10.1016/0378-1119(94)00824-c [doi]
PST - ppublish
SO  - Gene. 1995 Mar 10;154(2):243-7. doi: 10.1016/0378-1119(94)00824-c.