PMID- 7894246
OWN - NLM
STAT- MEDLINE
DCOM- 19950427
LR  - 20131121
IS  - 0940-2993 (Print)
IS  - 0940-2993 (Linking)
VI  - 46
IP  - 4-5
DP  - 1994 Oct
TI  - S-100 protein and glial fibrillary acidic protein (GFAP) in experimentally 
      induced and spontaneous tumours of peripheral nerves in BDVI rats. Light 
      microscopic and immunohistochemical study.
PG  - 343-53
AB  - Twenty-five ethylnitrosourea (ENU) induced and 24 spontaneous tumours of 
      peripheral nerves as well as 28 spontaneous mesenchymal tumours in BDVI rats were 
      studied by light microscopy and immunohistochemically for the presence of S-100 
      protein (S-100). Early ENU-induced schwannomas*) representing the thickenings of 
      nerves showed weak or negative S-100 immunoreactivity. S-100 positivity (both in 
      the cytoplasm and nucleus) was observed in all large ENU-induced tumours found in 
      animals dying or killed at advanced age. Immunostaining was present in both 
      cystic and solid areas of schwannomas. S-100 positivity was found in 20 of 24 
      spontaneous schwannomas: 14 of 20 positive tumours contained cysts. Twenty-seven 
      schwannomas (12 ENU-induced and 15 spontaneous) were studied for the presence of 
      glial fibrillar acid protein (GFAP) and 13 were positive (7 had cystic areas). 
      GFAP-positivity was relatively high in 4 tumours (3 ENU-induced and 1 
      spontaneous); these tumours also showed intense S-100 reactivity. 
      Immunoreactivity for S-100 occurred more frequently and was much more intense 
      than that for GFAP. The incidence of spontaneous peripheral nerve tumours in BDVI 
      males reached 4%, cystic schwannomas being the most frequent type. All 
      spontaneous mesenchymal tumours except lipoma (S-100 positive) were negative for 
      S-100 protein and for GFAP.
FAU - Turusov, V S
AU  - Turusov VS
AD  - Cancer Research Centre, Russian Academy of Medical Sciences, Moscow.
FAU - Cabral, J P
AU  - Cabral JP
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (S100 Proteins)
RN  - P8M1T4190R (Ethylnitrosourea)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/chemistry
MH  - Cytoplasm/chemistry
MH  - Ethylnitrosourea/toxicity
MH  - Female
MH  - Glial Fibrillary Acidic Protein/*analysis
MH  - Immunohistochemistry
MH  - Male
MH  - Mesenchymoma/chemically induced/*chemistry/pathology
MH  - Neurilemmoma/chemically induced/*chemistry/pathology
MH  - Peripheral Nervous System Neoplasms/chemically induced/*chemistry/pathology
MH  - Rats
MH  - S100 Proteins/*analysis
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - S0940-2993(11)80114-4 [pii]
AID - 10.1016/S0940-2993(11)80114-4 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 1994 Oct;46(4-5):343-53. doi: 10.1016/S0940-2993(11)80114-4.