PMID- 7895075
OWN - NLM
STAT- MEDLINE
DCOM- 19950424
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 667
IP  - 1
DP  - 1994 Dec 19
TI  - Intracerebroventricular treatment with an antisense oligodeoxynucleotide to 
      kappa-opioid receptors inhibited kappa-agonist-induced analgesia in rats.
PG  - 129-32
AB  - In vivo treatment with an antisense (AS) phosphorothioate oligodeoxynucleotide 
      (oligo) to the rat kappa-opioid receptor selectively inhibited kappa-mediated 
      analgesia in the rat cold-water tail-flick test. Intracerebroventricular (i.c.v.) 
      AS oligo significantly inhibited the analgesic effect of i.c.v. spiradoline, but 
      not that of mu- or delta-opioid agonists. The dose-effect curve for s.c. 
      spiradoline was shifted to the right after AS, but not missense or sense oligo 
      treatment. Thus, AS oligos provide another technique with which to selectively 
      manipulate opioid receptors and further support the role of non-mu opioid 
      receptors in mediating analgesia in rats.
FAU - Adams, J U
AU  - Adams JU
AD  - Department of Pharmacology, Temple University School of Medicine, Philadelphia, 
      PA 19140, USA.
FAU - Chen, X
AU  - Chen X
FAU - DeRiel, J K
AU  - DeRiel JK
FAU - Adler, M W
AU  - Adler MW
FAU - Liu-Chen, L Y
AU  - Liu-Chen LY
LA  - eng
GR  - DA00376/DA/NIDA NIH HHS/United States
GR  - DA04745/DA/NIDA NIH HHS/United States
GR  - T32 DA07237/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Pyrrolidines)
RN  - 0 (Receptors, Opioid, kappa)
RN  - N18ZH0M4NP (spiradoline)
SB  - IM
MH  - Analgesia
MH  - Animals
MH  - Base Sequence
MH  - Injections, Intraventricular
MH  - Male
MH  - Molecular Sequence Data
MH  - Oligonucleotides, Antisense/administration & dosage/genetics/*pharmacology
MH  - Pyrrolidines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Opioid, kappa/*antagonists & inhibitors
EDAT- 1994/12/19 00:00
MHDA- 1994/12/19 00:01
CRDT- 1994/12/19 00:00
PHST- 1994/12/19 00:00 [pubmed]
PHST- 1994/12/19 00:01 [medline]
PHST- 1994/12/19 00:00 [entrez]
AID - 0006-8993(94)91723-X [pii]
AID - 10.1016/0006-8993(94)91723-x [doi]
PST - ppublish
SO  - Brain Res. 1994 Dec 19;667(1):129-32. doi: 10.1016/0006-8993(94)91723-x.