PMID- 7895695
OWN - NLM
STAT- MEDLINE
DCOM- 19950425
LR  - 20131121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 136
IP  - 4
DP  - 1995 Apr
TI  - 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 
      beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked 
      mineralocorticoid activity on corticosterone in the ADX rat.
PG  - 1809-12
AB  - The effects of 11 alpha- and 11 beta-hydroxyprogesterone (11 alpha-OHP, 11 
      beta-OHP), on the activity of the glucocorticoid inactivating enzyme 11 
      beta-hydroxysteroid dehydrogenase (11 beta-HSD) were studied. 11 alpha-OHP and 11 
      beta-OHP were potent inhibitors of both 11 beta-HSD1 in rat liver microsomes and 
      11 beta-HSD2 in lysates of JEG-3 cells, a human choriocarcinoma cell line. In 
      addition, both progesterone metabolites were markedly potent in conferring 
      mineralocorticoid activity upon B in the adrenalectomized rat. These results 
      provide insight into the structural properties required of inhibitors of 11 
      beta-HSD activity and indicate a possible role for endogenous 11 beta-HSD 
      inhibitors in the regulation of glucocorticoid-induced Na+ retention.
FAU - Souness, G W
AU  - Souness GW
AD  - Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI.
FAU - Latif, S A
AU  - Latif SA
FAU - Laurenzo, J L
AU  - Laurenzo JL
FAU - Morris, D J
AU  - Morris DJ
LA  - eng
GR  - DK21404/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Hydroxyprogesterones)
RN  - 312-90-3 (11-hydroxyprogesterone)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - RWP5GA015D (Potassium)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - *Adrenalectomy
MH  - Animals
MH  - Choriocarcinoma/enzymology
MH  - Corticosterone/*pharmacology
MH  - Humans
MH  - Hydroxyprogesterones/*pharmacology
MH  - Hydroxysteroid Dehydrogenases/*antagonists & inhibitors/metabolism
MH  - Male
MH  - Microsomes, Liver/enzymology
MH  - Natriuresis/drug effects
MH  - Potassium/urine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Cells, Cultured
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1210/endo.136.4.7895695 [doi]
PST - ppublish
SO  - Endocrinology. 1995 Apr;136(4):1809-12. doi: 10.1210/endo.136.4.7895695.