PMID- 7895782
OWN - NLM
STAT- MEDLINE
DCOM- 19950426
LR  - 20231024
IS  - 0301-472X (Print)
IS  - 0301-472X (Linking)
VI  - 23
IP  - 4
DP  - 1995 Apr
TI  - Successful bone marrow transplantation by bone grafts in chimeric-resistant 
      combination.
PG  - 347-52
AB  - It has been shown that the bone marrow cells (BMCs) of DBA/2 mice do not readily 
      take in bone marrow from C57BL/6 mice, even if more than 5 x 10(6) cells are 
      injected. In this paper, we show that such chimerism resistance can be overcome 
      by cografting DBA/2 bones from which the hematopoietic cells have been removed 
      but in which the stromal cells remain. C57BL/6 mice reconstituted with BMCs plus 
      bones of DBA/2 mice survive significantly longer than C57BL/6 mice reconstituted 
      with DBA/2 BMC alone. In the former, not only the hematolymphoid cells but also 
      the stromal cells are replaced by donor-type cells, whereas in the latter, the 
      donor hematolymphoid cells are rejected. These findings indicate that the stromal 
      cells in the engrafted bones play a crucial role in the prevention of graft 
      rejection in bone marrow transplantation.
FAU - Hisha, H
AU  - Hisha H
AD  - First Department of Pathology, Kansai Medical University, Osaka, Japan.
FAU - Nishino, T
AU  - Nishino T
FAU - Kawamura, M
AU  - Kawamura M
FAU - Adachi, S
AU  - Adachi S
FAU - Ikehara, S
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (H-2 Antigens)
SB  - IM
MH  - Animals
MH  - *Bone Marrow Cells
MH  - Bone Marrow Transplantation/*pathology
MH  - H-2 Antigens/immunology
MH  - Hematopoiesis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Radiation Chimera
MH  - Time Factors
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
PST - ppublish
SO  - Exp Hematol. 1995 Apr;23(4):347-52.