PMID- 7896212
OWN - NLM
STAT- MEDLINE
DCOM- 19950425
LR  - 20131121
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 79
IP  - 6
DP  - 1994 Nov-Dec
TI  - Application of fluorescence in situ hybridization in defining a complex 
      t(9;21;22) Ph formation.
PG  - 536-9
AB  - We describe the application of fluorescence in situ hybridization (FISH) in a 
      case of suspected chronic myelogenous leukemia (CML), cytogenetically 
      characterized by a t(21;22) with no clear involvement of chromosome 9. The dual 
      color FISH technique, performed using specific painting probes for chromosomes 
      9,21,22 and a BCR/ABL translocation probe, enabled us to confirm the diagnosis of 
      CML by detecting the BCR/ABL rearrangement on chromosome 22q and the involvement 
      of chromosome 9 in a variant translocation t(9;21;22).
FAU - Mancini, M
AU  - Mancini M
AD  - Department of Human Biopathology, University La Sapienza, Rome, Italy.
FAU - Nanni, M
AU  - Nanni M
FAU - Cedrone, M
AU  - Cedrone M
FAU - De Cuia, M R
AU  - De Cuia MR
FAU - Rondinelli, M B
AU  - Rondinelli MB
FAU - Malagnino, F
AU  - Malagnino F
FAU - Alimena, G
AU  - Alimena G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
CIN - Haematologica. 1995 Mar-Apr;80(2):95-7. PMID: 7503878
GS  - BCR-ABL
MH  - Adult
MH  - Chromosomes, Human, Pair 21/*ultrastructure
MH  - Chromosomes, Human, Pair 22/*ultrastructure
MH  - Chromosomes, Human, Pair 9/*ultrastructure
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Male
MH  - *Philadelphia Chromosome
MH  - *Translocation, Genetic
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
PST - ppublish
SO  - Haematologica. 1994 Nov-Dec;79(6):536-9.