PMID- 7896364
OWN - NLM
STAT- MEDLINE
DCOM- 19950426
LR  - 20061115
IS  - 0019-6061 (Print)
IS  - 0019-6061 (Linking)
VI  - 31
IP  - 3
DP  - 1994 Mar
TI  - Immunological profile in congenital heart disease.
PG  - 295-300
AB  - Fifty children with established congenital heart disease (CHD) were surveyed for 
      the immune profile. Ventricular septal defect (VSD) was the commonest lesion 
      (56%) followed by Tetralogy of Fallot (ToF; 16%), atrial septal defect (ASD; 8%), 
      patent ductus arteriosus (PDA; 4%), transposition of great arteries (TGA; 4%), 
      aortic stenosis (AS; 4%), and pulmonic stenosis (PS), tricuspid atresia (TA), 
      single ventricle with pulmonic stenosis (SV with PS) and dextrocardia with ToF 
      (2% each). Immunoglobulins (IgG, IgA and IgM) were estimated. IgG and IgA levels 
      were significantly reduced in all children with congenital heart disease, whereas 
      IgM levels were increased in cyanotic but unaffected in the acyanotic group. 
      Complement C3 and C4 levels were reduced in all, more so in cyanotics. T-helper 
      cells were decreased and T-suppressor cells were increased in all groups with 
      congenital heart disease as compared to controls. B-cell percentage was increased 
      in cyanotics but not affected in the acyanotics.
FAU - Khalil, A
AU  - Khalil A
AD  - Department of Pediatrics, Maulana Azad Medical College, New Delhi.
FAU - Trehan, R
AU  - Trehan R
FAU - Tiwari, A
AU  - Tiwari A
FAU - Malik, R
AU  - Malik R
FAU - Arora, R
AU  - Arora R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Antibody Formation
MH  - B-Lymphocytes
MH  - Child, Preschool
MH  - Female
MH  - Heart Defects, Congenital/*immunology
MH  - Humans
MH  - Immunoglobulin A/*blood
MH  - Immunoglobulin G/*blood
MH  - Immunoglobulin M/*blood
MH  - Male
MH  - T-Lymphocytes
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
PST - ppublish
SO  - Indian Pediatr. 1994 Mar;31(3):295-300.