PMID- 7900542
OWN - NLM
STAT- MEDLINE
DCOM- 19950425
LR  - 20200106
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 12
IP  - 7
DP  - 1994 Nov
TI  - The effects of reduced perfusion and reperfusion on c-fos and HSP-72 protein 
      immunohistochemistry in gestational day 21 rat brains.
PG  - 605-10
AB  - Metabolic stressors such as hyperthermia, seizures and ischemic hypoxia result in 
      the induction of c-fos and heat-shock proteins (HSP) in affected brain cells of 
      the adult rodent, especially within the hippocampal region, which normally has 
      high metabolic demands. Here we ligated the uterine vessels of gestational day 
      (GD) 21 rat pups to produce ischemic hypoxia. We confirmed that HSP-72 protein, 
      as previously reported, was activated in the perinatal rat pup, especially in the 
      hippocampal CA3 region. However, the capability of hippocampal cells to produce 
      c-fos protein following drug-induced seizures has been reported to develop only 
      after postnatal day 13. Here, ischemic hypoxia caused CA1 hippocampal cells to 
      produce immunohistochemically detectable c-fos protein in GD-21 rats. These 
      results seem to contradict the previous reports of no c-fos induction in rats 
      this young by demonstrating a functional c-fos translational mechanism by GD-21. 
      However, seizure vs ischemic hypoxia-induced c-fos expression may involve several 
      different pre-translational pathways. A delayed development of a receptor, second 
      messenger, or genomic element for regulating c-fos transcription remain as 
      possible explanations for the late maturity of responsivity to seizures.
FAU - Binienda, Z
AU  - Binienda Z
AD  - Division of Neurotoxicology, Food and Drug Administration, Jefferson, AR 
      72079-9502.
FAU - Scallet, A C
AU  - Scallet AC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (HSP72 Heat-Shock Proteins)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
GS  - c-fos
MH  - Animals
MH  - Brain Chemistry/*physiology
MH  - Brain Ischemia/metabolism
MH  - Cerebrovascular Circulation/*physiology
MH  - Female
MH  - HSP72 Heat-Shock Proteins
MH  - Heat-Shock Proteins/*metabolism
MH  - Hippocampus/metabolism
MH  - Hypoxia, Brain/metabolism
MH  - Immunohistochemistry
MH  - Pregnancy
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/*metabolism
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 0736-5748(94)90012-4 [pii]
AID - 10.1016/0736-5748(94)90012-4 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 1994 Nov;12(7):605-10. doi: 10.1016/0736-5748(94)90012-4.