PMID- 7901132
OWN - NLM
STAT- MEDLINE
DCOM- 19931206
LR  - 20190830
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 60
IP  - 3
DP  - 1993 Aug
TI  - A study of the precursors, intermediates and reaction by-products in the 
      synthesis of 3,4-methylenedioxymethylamphetamine and its application to forensic 
      drug analysis.
PG  - 189-202
AB  - 3,4-Methylenedioxymethylamphetamine (MDMA) was prepared by three synthetic 
      routes. Analytical data from thin-layer chromatography, gas chromatography and 
      gas chromatography-mass spectrometry of the precursors (safrole and isosafrole), 
      intermediates (isosafrole glycol, piperonylmethylketone, 
      N-formyl-3,4-methylenedioxymethylamphetamine, 
      N-formyl-3,4-methylenedioxyamphetamine and 
      1-(3,4-methylenedioxyphenyl)-2-bromopropane), reaction by-products and the 
      product MDMA were obtained. Further analyses of MDMA using other techniques 
      including 1H- and 13C-nuclear magnetic resonance spectroscopy, X-ray diffraction, 
      infrared spectroscopy, ultraviolet spectroscopy and high performance liquid 
      chromatography were also carried out. The results were then used as reference 
      data for the identification of MDMA in case samples and also to establish the 
      route of synthesis of illicitly prepared MDMA by the study of trace impurities.
FAU - Renton, R J
AU  - Renton RJ
AD  - Metropolitan Police Forensic Science Laboratory, London (UK).
FAU - Cowie, J S
AU  - Cowie JS
FAU - Oon, M C
AU  - Oon MC
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Designer Drugs)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/analysis/chemical synthesis
MH  - *Designer Drugs
MH  - Drug and Narcotic Control/legislation & jurisprudence
MH  - England
MH  - Forensic Medicine
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Substance-Related Disorders/diagnosis
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 0379-0738(93)90238-6 [pii]
AID - 10.1016/0379-0738(93)90238-6 [doi]
PST - ppublish
SO  - Forensic Sci Int. 1993 Aug;60(3):189-202. doi: 10.1016/0379-0738(93)90238-6.