PMID- 7901784
OWN - NLM
STAT- MEDLINE
DCOM- 19931222
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 57
IP  - 6
DP  - 1993 Jun
TI  - Pituitary adenylate cyclase-activating polypeptide stimulates arginine 
      vasopressin release in conscious rats.
PG  - 1092-6
AB  - The effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on 
      arginine vasopressin (AVP) release was investigated in conscious rats. 
      Intracerebroventricular (i.c.v.) administration of PACAP raised the plasma AVP 
      concentration in a dose-dependent manner (50-500 pmol/rat), and the maximum 
      effect was obtained at 5 min after the administration. This AVP-releasing effect 
      was not due to a fall of blood pressure, increase of plasma Na or decrease of 
      plasma volume, all of which are known to stimulate AVP release. PACAP had little 
      effect on blood pressure at a low dose, but at higher doses increased it. 
      Vasoactive intestinal peptide (VIP), which is homologous to PACAP, also raised 
      the plasma AVP concentration by i.c.v. injection. An antagonist for VIP receptor, 
      [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but 
      had little effect on PACAP-induced increase of plasma AVP. These results suggest 
      that PACAP stimulates AVP release, via specific receptors which are distinct from 
      VIP receptors.
FAU - Murase, T
AU  - Murase T
AD  - First Department of Internal Medicine, Nagoya University School of Medicine, 
      Japan.
FAU - Kondo, K
AU  - Kondo K
FAU - Otake, K
AU  - Otake K
FAU - Oiso, Y
AU  - Oiso Y
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Adcyap1 protein, rat)
RN  - 0 (Neuropeptides)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Pituitary Adenylate Cyclase-Activating Polypeptide)
RN  - 0 (Receptors, Vasoactive Intestinal Peptide)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*metabolism
MH  - Blood Pressure/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptides/administration & dosage/*pharmacology
MH  - Neurotransmitter Agents/administration & dosage/*pharmacology
MH  - Pituitary Adenylate Cyclase-Activating Polypeptide
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Vasoactive Intestinal Peptide/drug effects
MH  - Vasoactive Intestinal Peptide/antagonists & inhibitors
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 10.1159/000126475 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1993 Jun;57(6):1092-6. doi: 10.1159/000126475.