PMID- 7901927
OWN - NLM
STAT- MEDLINE
DCOM- 19931214
LR  - 20221007
IS  - 0300-8916 (Print)
IS  - 0300-8916 (Linking)
VI  - 79
IP  - 3
DP  - 1993 Jun 30
TI  - PCNA/cyclin and P-glycoprotein as prognostic factors in locally advanced breast 
      cancer. An immunohistochemical, retrospective study.
PG  - 214-8
AB  - AIMS AND BACKGROUND: The aim of the present study was to determine, 
      retrospectively, whether the immunohistochemical expression of two biologic 
      markers of aggressively, P-glycoprotein (P-gp) and PCNA/cyclin (PCNA), could be 
      related to response to chemotherapy and prognosis in locally advanced breast 
      cancer. METHODS: PC 10 Mab was used to determine the proliferation index (PCNA) 
      and C-219 Mab to determine P-gp in 25 locally advanced breast carcinomas 
      subjected to preoperative chemotherapy with MDR-related drugs. RESULTS: P-gp and 
      PCNA were expressed in 76% and 100% of the tumors, respectively. No case of high 
      P-gp expression was associated with good chemosensitivity, and all P-gp-negative 
      cases showed the best chemotherapeutic response. P-gp and PCNA were both highly 
      expressed in patients who developed local-regional or distant metastases. No 
      recurrence was associated with a negative or low P-gp score. CONCLUSIONS: 
      Statistical analysis showed that high P-gp expression was related to a poor 
      response to chemotherapy and a short disease-free survival. A high PCNA score was 
      not found to be significant for predicting chemosensitivity or survival.
FAU - Botti, G
AU  - Botti G
AD  - Istituto Nazionale dei Tumori, Fondazione G. Pascale, Napoli, Italy.
FAU - Chiappetta, G
AU  - Chiappetta G
FAU - D'Aiuto, G
AU  - D'Aiuto G
FAU - de Angelis, E
AU  - de Angelis E
FAU - De Matteis, A
AU  - De Matteis A
FAU - Montella, M
AU  - Montella M
FAU - Picone, A
AU  - Picone A
FAU - Cascione, F
AU  - Cascione F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumori
JT  - Tumori
JID - 0111356
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1
MH  - Adult
MH  - Antigens, Neoplasm/*analysis
MH  - Biomarkers/analysis
MH  - Breast Neoplasms/*chemistry/drug therapy/mortality/pathology
MH  - Carrier Proteins/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Membrane Glycoproteins/*analysis
MH  - Middle Aged
MH  - Neoplasm Proteins/*analysis
MH  - Nuclear Proteins/*analysis
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen
MH  - Retrospective Studies
MH  - Survival Analysis
EDAT- 1993/06/30 00:00
MHDA- 1993/06/30 00:01
CRDT- 1993/06/30 00:00
PHST- 1993/06/30 00:00 [pubmed]
PHST- 1993/06/30 00:01 [medline]
PHST- 1993/06/30 00:00 [entrez]
AID - 10.1177/030089169307900312 [doi]
PST - ppublish
SO  - Tumori. 1993 Jun 30;79(3):214-8. doi: 10.1177/030089169307900312.