PMID- 7902981
OWN - NLM
STAT- MEDLINE
DCOM- 19940110
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 46
IP  - 1
DP  - 1993 Sep
TI  - Comparison of conditioned taste aversions produced by MDMA and d-amphetamine.
PG  - 153-6
AB  - Many drugs of abuse such as d-amphetamine support the development of taste 
      aversion in a conditioned taste aversion paradigm. However, it has yet to be 
      established whether methylenedioxymethamphetamine (MDMA), an amphetamine-like 
      stimulant, has this property. A direct comparison was made between MDMA and 
      d-amphetamine over a dose range of 0.125-2.0 mg/kg (SC). Two pairings of either 
      drug with saccharin produced dose-related taste aversions to saccharin that were 
      retained for at least three successive testing trials. The minimally effective 
      dose was 1 mg/kg for MDMA and 0.5 mg/kg for d-amphetamine. The relative potency 
      of MDMA to amphetamine was 4.5, similar to that previously reported for drug 
      discrimination and self-stimulation.
FAU - Lin, H Q
AU  - Lin HQ
AD  - Department of Pharmacology, University of Sydney, N.S.W., Australia.
FAU - Atrens, D M
AU  - Atrens DM
FAU - Christie, M J
AU  - Christie MJ
FAU - Jackson, D M
AU  - Jackson DM
FAU - McGregor, I S
AU  - McGregor IS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Designer Drugs)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Designer Drugs/*pharmacology
MH  - Dextroamphetamine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Wistar
MH  - Taste/*drug effects
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 0091-3057(93)90333-O [pii]
AID - 10.1016/0091-3057(93)90333-o [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1993 Sep;46(1):153-6. doi: 10.1016/0091-3057(93)90333-o.