PMID- 7903503
OWN - NLM
STAT- MEDLINE
DCOM- 19940124
LR  - 20190909
IS  - 0168-1702 (Print)
IS  - 0168-1702 (Linking)
VI  - 30
IP  - 1
DP  - 1993 Oct
TI  - Evolution of mouse mammary tumor virus-related sequences in the human genome.
PG  - 53-61
AB  - The human genome contains numerous copies of elements with sequence homology to 
      the mouse mammary tumor virus (MMTV). We have been interested in whether these 
      elements are still actively transposing in the germ lines, and investigated this 
      question by looking at restriction fragment patterns. Genomic DNA from humans and 
      selected animals were digested with three different restriction enzymes and 
      hybridized with five probes representative of five subgroups of the human 
      MMTV-related elements. Two polymorphisms as well as two cases of sexual 
      dimorphism were discovered in human DNA. The latter indicate the presence of at 
      least two elements of the MMTV family on the Y chromosome. DNA samples from 
      non-primate mammals were all unreactive. Both chimpanzee and rhesus monkey had 
      restriction patterns of roughly the same number of bands and total intensity as 
      humans. The number of differences in patterns between humans, and between humans 
      and chimpanzee or rhesus monkey, were compatible with being caused by point 
      mutations. The data indicate that these elements were actively spreading in the 
      genome some time before the split between apes and Old World monkeys, while being 
      relatively inactive, at least as to transpositions in the germ line, in later 
      ages.
FAU - Sorhaug, H
AU  - Sorhaug H
AD  - Department of Virology, National Institute of Public Health, Oslo, Norway.
FAU - Grinde, B
AU  - Grinde B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - *Biological Evolution
MH  - DNA/*genetics
MH  - Female
MH  - *Genome, Human
MH  - Humans
MH  - Male
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - *Polymorphism, Restriction Fragment Length
MH  - *Sequence Homology
MH  - Sex Characteristics
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 0168-1702(93)90015-F [pii]
AID - 10.1016/0168-1702(93)90015-f [doi]
PST - ppublish
SO  - Virus Res. 1993 Oct;30(1):53-61. doi: 10.1016/0168-1702(93)90015-f.