PMID- 7904671
OWN - NLM
STAT- MEDLINE
DCOM- 19940224
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 343
IP  - 8891
DP  - 1994 Jan 22
TI  - Human T-lymphotropic virus type I in Japan.
PG  - 213-6
AB  - Adult T-cell leukaemia (ATL) was first reported in Japan, where it has a high 
      incidence in the southwest region. The retrovirus human T-lymphotropic virus type 
      I (HTLV-I) is the cause of ATL; and in ATL-endemic areas, the rate of carriage of 
      antibodies to HTLV-I is high. A definite diagnosis of ATL is based on the 
      presence of HTLV-I proviral DNA in the tumour-cell DNA. ATL cells originate from 
      the CD4 subset of peripheral T cells. ATL shows diverse clinical features but can 
      be divided into four subtypes--acute, chronic, smouldering, and lymphoma type. It 
      is resistant to chemotherapy, and the acute and lymphoma types have a poor 
      prognosis. Familial occurrence of ATL is common. HTLV-I infection is caused by 
      transmission of live infected lymphocytes from mother to child, from man to 
      woman, or by transfusion. Infection with HTLV-I can lead to other diseases, 
      including HTLV-I-associated myelopathy/tropical spastic paraparesis and HTLV-I 
      uveitis, possibly via induction of immunodeficiency or hyperreactivity against 
      HTLV-I-infected cells.
FAU - Yamaguchi, K
AU  - Yamaguchi K
AD  - Blood Transfusion Service, Kumamoto University School of Medicine, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (DNA, Viral)
RN  - 0 (HTLV-I Antibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - DNA, Viral/analysis
MH  - Female
MH  - HTLV-I Antibodies/blood
MH  - HTLV-I Infections/blood/*complications/*epidemiology/prevention & 
      control/transmission
MH  - *Human T-lymphotropic virus 1
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Leukemia, T-Cell/classification/*epidemiology/*microbiology/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - *Population Surveillance
MH  - Prognosis
MH  - Seroepidemiologic Studies
RF  - 33
EDAT- 1994/01/22 00:00
MHDA- 1994/01/22 00:01
CRDT- 1994/01/22 00:00
PHST- 1994/01/22 00:00 [pubmed]
PHST- 1994/01/22 00:01 [medline]
PHST- 1994/01/22 00:00 [entrez]
AID - S0140-6736(94)90994-6 [pii]
AID - 10.1016/s0140-6736(94)90994-6 [doi]
PST - ppublish
SO  - Lancet. 1994 Jan 22;343(8891):213-6. doi: 10.1016/s0140-6736(94)90994-6.