PMID- 7904784
OWN - NLM
STAT- MEDLINE
DCOM- 19940222
LR  - 20190914
IS  - 0174-7398 (Print)
IS  - 0174-7398 (Linking)
VI  - 423
IP  - 6
DP  - 1993
TI  - Immunohistochemical location of prothymosin alpha in regenerating human 
      hepatocytes and hepatocellular carcinomas.
PG  - 449-52
AB  - In the present paper we analysed the presence of prothymosin alpha (ProT) in 
      human liver. In normal liver, ProT immunostaining was found in the nuclei of bile 
      duct cells, but not in the hepatocytes. In contrast an intense immunoreactivity 
      was observed in regenerative hepatocytes of chronic hepatitis, cirrhosis and in 
      hepatocellular carcinomas. In all cases the immunostaining was restricted to the 
      nuclei, but the nucleoli were always negative. Similar results were obtained for 
      proliferating cell nuclear antigen. These findings confirm that ProT is related 
      to cell proliferation and provides a new immunohistochemical proliferation marker 
      for routinely processed samples.
FAU - Fraga, M
AU  - Fraga M
AD  - Departamento de Anatomia Patologica, Facultad de Medicina-Hospital General de 
      Galicia, Universidad de Santiago, Santiago de Compostela, Spain.
FAU - Garcia-Caballero, T
AU  - Garcia-Caballero T
FAU - Dominguez, F
AU  - Dominguez F
FAU - Perez-Becerra, E
AU  - Perez-Becerra E
FAU - Beiras, A
AU  - Beiras A
FAU - Forteza, J
AU  - Forteza J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Virchows Arch A Pathol Anat Histopathol
JT  - Virchows Archiv. A, Pathological anatomy and histopathology
JID - 8302198
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 0 (Protein Precursors)
RN  - 0 (prothymosin alpha)
RN  - 61512-21-8 (Thymosin)
SB  - IM
MH  - Carcinoma, Hepatocellular/*chemistry/pathology
MH  - Cell Division
MH  - *Hepatitis, Chronic/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver/*chemistry/cytology
MH  - *Liver Cirrhosis/pathology
MH  - Liver Neoplasms/*chemistry/pathology
MH  - Nuclear Proteins/analysis
MH  - Proliferating Cell Nuclear Antigen
MH  - Protein Precursors/*analysis
MH  - Thymosin/*analogs & derivatives/analysis
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1007/BF01606534 [doi]
PST - ppublish
SO  - Virchows Arch A Pathol Anat Histopathol. 1993;423(6):449-52. doi: 
      10.1007/BF01606534.