PMID- 7904883
OWN - NLM
STAT- MEDLINE
DCOM- 19940302
LR  - 20191023
IS  - 1350-7540 (Print)
IS  - 1350-7540 (Linking)
VI  - 6
IP  - 6
DP  - 1993 Dec
TI  - Alzheimer's disease and Creutzfeldt-Jakob disease: overlap of pathogenic 
      mechanisms.
PG  - 872-81
AB  - This article compares beta-amyloid precursor protein (beta-APP) disorders 
      exemplified by Alzheimer's disease (AD), with prion protein (PrP) disorders, 
      exemplified by Creutzfeldt-Jakob disease (CJD) in humans and scrapie in animals. 
      Although there are obvious differences in the etiology and pathogenesis of both 
      sets of disorders, a remarkable number of similarities exist. Both sets of 
      disorders are characterized clinically by age-related sporadic and familial 
      diseases. In both, an abnormal form of a neuronal membrane protein appears to 
      play a key role in the pathogenesis: beta-A4 peptide in AD and PrPCJD in CJD. 
      Both beta-A4 and PrPCJD are amyloidogenic. Neuritic plaques characteristic of AD 
      were once thought to be exclusively associated with beta-A4 amyloid; however, 
      some pedigrees with familial prion disease produced neuritic plaques with PrP 
      amyloid cores. Finally, beta-APP accumulation in skeletal muscle has been 
      implicated in the age-related muscle disorder, inclusion body myositis. A similar 
      myopathy has recently been discovered in transgenic mice expressing high levels 
      of normal PrP. These similarities suggest that what is learned about one set of 
      disorders may be applicable to the other.
FAU - DeArmond, S J
AU  - DeArmond SJ
AD  - Department of Pathology, University of California, San Francisco 94143-0506.
LA  - eng
GR  - AG02132/AG/NIA NIH HHS/United States
GR  - NS14069/NS/NINDS NIH HHS/United States
GR  - NS22786/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Curr Opin Neurol
JT  - Current opinion in neurology
JID - 9319162
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (PrPSc Proteins)
RN  - 0 (Prions)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*etiology/genetics/pathology
MH  - Amyloid beta-Protein Precursor/*analysis/genetics
MH  - Animals
MH  - Brain/pathology
MH  - Creutzfeldt-Jakob Syndrome/*etiology/genetics/pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Mutation/genetics
MH  - PrPSc Proteins
MH  - Prions/*analysis/genetics
RF  - 76
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1097/00019052-199312000-00008 [doi]
PST - ppublish
SO  - Curr Opin Neurol. 1993 Dec;6(6):872-81. doi: 10.1097/00019052-199312000-00008.