PMID- 7905245
OWN - NLM
STAT- MEDLINE
DCOM- 19940303
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 127
IP  - 2
DP  - 1994 Feb
TI  - Anti-beta-receptor antibodies in familial cardiomyopathy: correlation with HLA-DR 
      and HLA-DQ gene polymorphisms.
PG  - 382-6
AB  - The presence of beta-receptor autoantibodies and their relationship to 
      restriction fragment length polymorphisms of the human leukocyte antigen (HLA) 
      class II genes were studied in 42 affected and unaffected members of a family 
      with a heritable disorder of the conduction system and cardiac muscle. Antibodies 
      were detected in 34% of all members (59% of affected and 22% of unaffected; p < 
      0.01). Significant differences between affected and unaffected individuals and 
      between anti-beta-receptor antibody positive and negative individuals were noted 
      in the prevalence of polymorphisms obtained with Taq I for the HLA-DR beta and 
      HLA-DQ alpha genes. In affected individuals, there was a strong positive 
      correlation between these polymorphisms and the presence of anti-beta-receptor 
      antibodies. These results suggest that autoimmune mechanisms under the control of 
      the class II genes play an important role in the pathogenesis of familial 
      cardiomyopathy.
FAU - Limas, C
AU  - Limas C
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota Medical 
      School, Minneapolis 55455.
FAU - Limas, C J
AU  - Limas CJ
FAU - Boudoulas, H
AU  - Boudoulas H
FAU - Bair, R
AU  - Bair R
FAU - Graber, H
AU  - Graber H
FAU - Sparks, L
AU  - Sparks L
FAU - Wooley, C F
AU  - Wooley CF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (Receptors, Adrenergic, beta)
SB  - IM
MH  - Arrhythmias, Cardiac/genetics/immunology
MH  - Autoantibodies/*genetics
MH  - Biomarkers
MH  - Cardiomegaly/genetics/immunology
MH  - Cardiomyopathy, Dilated/*genetics/*immunology
MH  - Disease Susceptibility/immunology
MH  - Female
MH  - Genes, MHC Class II/*genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR4 Antigen/genetics
MH  - Heart Block/genetics/immunology
MH  - Heart Failure/genetics/immunology
MH  - Humans
MH  - Male
MH  - Phenotype
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Receptors, Adrenergic, beta/genetics/*immunology
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0002-8703(94)90128-7 [pii]
AID - 10.1016/0002-8703(94)90128-7 [doi]
PST - ppublish
SO  - Am Heart J. 1994 Feb;127(2):382-6. doi: 10.1016/0002-8703(94)90128-7.