PMID- 7906223
OWN - NLM
STAT- MEDLINE
DCOM- 19940322
LR  - 20151119
IS  - 0012-0472 (Print)
IS  - 0012-0472 (Linking)
VI  - 119
IP  - 5
DP  - 1994 Feb 4
TI  - [Thymus carcinoid in multiple endocrine neoplasms type I].
PG  - 135-40
AB  - Thrombosis of the left subclavian vein occurred in a 44-year-old man. It was 
      found to be caused by an atypical thymus carcinoid of the anterior mediastinum 
      without carcinoid syndrome. Primary resection was not possible, but it was 
      removed after three cycles of neoadjuvant chemotherapy with doxorubicin, 
      cisplatin, vincristine and cyclophosphamide. Increased concentrations of alkaline 
      phosphatase and parathormone were then noted. Subtotal parathyroidectomy revealed 
      hyperplastic parathyroids. A gastrinoma was suspected from a history of peptic 
      ulcer for many years which had persisted despite a Billroth II gastric resection 
      10 years ago. Serum gastrin, analysis of gastric secretion and a 
      secretin-stimulating test confirmed the diagnosis. Recurrent episodes of weakness 
      and syncope, in the presence of low blood sugar levels and a positive C-peptide 
      suppression test, were interpreted as due to an insulinoma. There was no evidence 
      of increased hypophyseal or adrenal function. Finally, in the absence of a family 
      history, multiple endocrine neoplasia type 1 (MEN 1) was diagnosed with 
      co-existing primary hyperparathyroidism, gastrinoma, insulinoma and thymus 
      carcinoid. Somatostatin-receptor scintigraphy provided localization of the MEN 1 
      with enrichment in the thorax and abdomen.
FAU - Zahner, J
AU  - Zahner J
AD  - Klinik fur Hamatologie, Onkologie und klinische Immunologie, Universitat 
      Dusseldorf.
FAU - Borchard, F
AU  - Borchard F
FAU - Schmitz, U
AU  - Schmitz U
FAU - Schneider, W
AU  - Schneider W
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Thymuskarzinoid bei multipler endokriner Neoplasie Typ I.
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
RN  - 5J49Q6B70F (Vincristine)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - 9005-49-6 (Heparin)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Carcinoid Tumor/complications/*diagnosis/therapy
MH  - Cisplatin/administration & dosage
MH  - Combined Modality Therapy
MH  - Cyclophosphamide/administration & dosage
MH  - Gastrinoma/diagnosis
MH  - Heparin/administration & dosage
MH  - Humans
MH  - Hyperparathyroidism/diagnosis
MH  - Insulinoma/diagnosis
MH  - Male
MH  - Multiple Endocrine Neoplasia/complications/*diagnosis/therapy
MH  - Pancreatic Neoplasms/diagnosis
MH  - Parathyroidectomy
MH  - Subclavian Vein
MH  - Thrombosis/diagnosis/drug therapy/etiology
MH  - Thymus Neoplasms/complications/*diagnosis/therapy
MH  - Vincristine/administration & dosage
EDAT- 1994/02/04 00:00
MHDA- 1994/02/04 00:01
CRDT- 1994/02/04 00:00
PHST- 1994/02/04 00:00 [pubmed]
PHST- 1994/02/04 00:01 [medline]
PHST- 1994/02/04 00:00 [entrez]
AID - 10.1055/s-2008-1058672 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 1994 Feb 4;119(5):135-40. doi: 10.1055/s-2008-1058672.