PMID- 7906293
OWN - NLM
STAT- MEDLINE
DCOM- 19940323
LR  - 20231213
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 169
IP  - 2
DP  - 1994 Feb
TI  - Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors 
      in human immunodeficiency virus type 1 infection--correlations to clinical, 
      immunologic, and virologic parameters.
PG  - 420-4
AB  - Two EIAs (Medgenix and Quantikine) and a bioassay were used to measure tumor 
      necrosis factor-alpha (TNF alpha) in serum samples from 73 human immunodeficiency 
      virus type 1 (HIV-1)-seropositive patients and in samples from 2 control groups. 
      All clinical groups of HIV-1-infected patients, regardless of concurrent illness, 
      had significantly elevated levels of both types of soluble TNF receptors (sTNFRs) 
      and immunoreactive TNF alpha (Medgenix EIA), with the highest concentrations 
      among the AIDS patients. These TNF parameters were significantly correlated with 
      reduced CD4+ lymphocyte counts. Only a few HIV-1-infected patients had detectable 
      TNF alpha levels measured by the Quantikine EIA. TNF alpha bioactivity was 
      significantly raised only in the AIDS group. Serially measured sTNFRs, expressed 
      as sTNFR slopes, were significantly associated with survival in the patient 
      group. The raised levels of immunoreactive TNF alpha and sTNFRs strongly indicate 
      activation of the TNF alpha system during HIV-1 infection. Levels increase with 
      disease progression and degree of immunodeficiency; thus, serially measured 
      sTNFRs may give useful prognostic information in HIV-1 infection.
FAU - Aukrust, P
AU  - Aukrust P
AD  - Section of Clinical Immunology and Infectious Diseases, Medical Department A, 
      Rikshospitalet, Oslo, Norway.
FAU - Liabakk, N B
AU  - Liabakk NB
FAU - Muller, F
AU  - Muller F
FAU - Lien, E
AU  - Lien E
FAU - Espevik, T
AU  - Espevik T
FAU - Froland, S S
AU  - Froland SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Biopterins)
RN  - 670-65-5 (Neopterin)
SB  - IM
EIN - J Infect Dis 1994 May;169(5):1186-7
MH  - Adult
MH  - Biopterins/analogs & derivatives/blood
MH  - CD4-Positive T-Lymphocytes
MH  - HIV Infections/*blood
MH  - HIV Seropositivity/blood
MH  - Humans
MH  - Leukocyte Count
MH  - Neopterin
MH  - Receptors, Tumor Necrosis Factor/chemistry/*metabolism
MH  - Solubility
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1093/infdis/169.2.420 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Feb;169(2):420-4. doi: 10.1093/infdis/169.2.420.