PMID- 7906302
OWN - NLM
STAT- MEDLINE
DCOM- 19940324
LR  - 20200220
IS  - 0894-9255 (Print)
IS  - 0894-9255 (Linking)
VI  - 7
IP  - 3
DP  - 1994 Mar
TI  - Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during 
      HIV-1 infection.
PG  - 245-53
AB  - A progressive significant decrease of CD28 surface antigen expression on CD4+ 
      (mean, 90, 86, 79, 68% in stages I, II, III, and IV, respectively, versus 96% in 
      normals), as well as on CD8+ T lymphocytes (mean, 38, 32, 31, and 29% in stages 
      I, II, III, and IV, respectively, versus 47% in normals) was observed during 
      HIV-1 infection. The increase of cytotoxic/suppressor T cells, in both percentage 
      and absolute numbers, that was observed in almost all HIV-1 patients, was 
      associated with an increase of the CD8+ cells lacking the CD28 surface antigen. 
      The loss of CD28 antigen expression was parallel to the increase of CD38, human 
      leukocyte antigen (HLA)-DR, and CD45RO antigen expression on T lymphocytes 
      throughout the disease. Furthermore, a positive significant correlation within 
      the CD4+ but not the CD8+ subset was observed between the percentage of cells 
      lacking the CD28 antigen and the percentage of cells expressing the HLA-DR and 
      CD38 antigens, a finding suggesting that the loss of CD28 antigen expression on 
      CD4+ lymphocytes may be associated with T-lymphocyte activation. Patients treated 
      with zidovudine showed no significant differences in the percentages of either 
      CD4+CD28+ or CD8+CD28+ T-cell subsets when compared to untreated patients. These 
      phenotypic changes may be associated with the functional defects of T lymphocytes 
      in HIV-1 infected individuals.
FAU - Choremi-Papadopoulou, H
AU  - Choremi-Papadopoulou H
AD  - Dept of Immunology, Laiko General Hospital, Athens, Greece.
FAU - Viglis, V
AU  - Viglis V
FAU - Gargalianos, P
AU  - Gargalianos P
FAU - Kordossis, T
AU  - Kordossis T
FAU - Iniotaki-Theodoraki, A
AU  - Iniotaki-Theodoraki A
FAU - Kosmidis, J
AU  - Kosmidis J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr (1988)
JT  - Journal of acquired immune deficiency syndromes
JID - 8812597
RN  - 0 (CD28 Antigens)
RN  - 4B9XT59T7S (Zidovudine)
SB  - IM
MH  - Adult
MH  - CD28 Antigens/*metabolism
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - *Down-Regulation
MH  - Female
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - HIV Infections/drug therapy/*immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocyte Subsets/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Zidovudine/therapeutic use
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
PST - ppublish
SO  - J Acquir Immune Defic Syndr (1988). 1994 Mar;7(3):245-53.