PMID- 7908446
OWN - NLM
STAT- MEDLINE
DCOM- 19940502
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 47
IP  - 2
DP  - 1994 Feb
TI  - MDMA enhances associative and nonassociative learning in the rabbit.
PG  - 289-93
AB  - The rate of associative learning was assessed in the presence of saline versus 
      methylenedioxymethamphetamine (MDMA) at doses of 0.95, 1.9, and 3.8 mg/kg. The 
      conditioned stimuli (CSs) were lights and tones and the unconditioned stimulus 
      (US) was a corneal air puff. Learning was enhanced by all but the highest dose of 
      drug tested, and the enhancement was most pronounced when light was used as the 
      conditioned stimulus. Nonassociative responding was assessed using unpaired 
      presentations of the lights, tones, and air puffs. MDMA (1.9 mg/kg) produced a 
      slight increase in the percentage of baseline responses but failed to produce an 
      increase in the frequency of nonassociative responding in the presence of the 
      lights or tones. MDMA produced a significant increase in the amplitude of the 
      unconditioned response to the corneal air puff across the 10 sessions. This 
      increase was taken as evidence for sensitization of the unconditioned response, a 
      nonassociative learning phenomenon. In summary, MDMA, like the parent compound 
      methylenedioxyamphetamine (MDA), enhances both conditioned and unconditioned 
      responding. Because this dual effect has not been seen with related psychedelic 
      compounds, the effect appears to be unique to this class of phenylethylamine 
      drugs.
FAU - Romano, A G
AU  - Romano AG
AD  - Department of Pharmacology, Medical College of Pennsylvania, Eastern Pennsylvania 
      Psychiatric Institute, Philadelphia 19129.
FAU - Harvey, J A
AU  - Harvey JA
LA  - eng
GR  - DA04944/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Association Learning/*drug effects
MH  - Conditioning, Classical/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nictitating Membrane/drug effects
MH  - Physical Stimulation
MH  - Rabbits
MH  - Stimulation, Chemical
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0091-3057(94)90012-4 [pii]
AID - 10.1016/0091-3057(94)90012-4 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1994 Feb;47(2):289-93. doi: 
      10.1016/0091-3057(94)90012-4.