PMID- 7908448
OWN - NLM
STAT- MEDLINE
DCOM- 19940502
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 47
IP  - 2
DP  - 1994 Feb
TI  - Contrasting effects of dopaminergic blockade on MDMA and d-amphetamine 
      conditioned taste aversions.
PG  - 369-74
AB  - A series of experiments examined the role of dopamine in the conditioned taste 
      aversion (CTA) produced by 3,4-methylenedioxymethamphetamine (MDMA) and 
      d-amphetamine in rats. The CTA induced by MDMA (1.0 mg/kg) was unaffected by the 
      D1 dopamine receptor antagonist SCH23390 (0.3 or 0.6 mg/kg), the D2 receptor 
      antagonist raclopride (0.3 or 0.6 mg/kg), SCH23390 and raclopride combined (both 
      0.3 or 0.6 mg/kg), or the D1/D2 receptor antagonist haloperidol (0.4 mg/kg). In 
      contrast, the CTA produced by d-amphetamine (0.5 mg/kg) was attenuated by 
      SCH23390 and raclopride combined (both 0.3 mg/kg) as well as haloperidol (0.4 
      mg/kg), but not by SCH23390 (0.3 or 0.6 mg/kg) or raclopride (0.3 or 0.6 mg/kg) 
      alone. These results suggest that dopamine plays different roles in MDMA and 
      amphetamine CTAs, and that the D1 and D2 receptors independently mediate the 
      aversive effect of amphetamine in CTA.
FAU - Lin, H Q
AU  - Lin HQ
AD  - Department of Pharmacology, University of Sydney, N.S.W., Australia.
FAU - McGregor, I S
AU  - McGregor IS
FAU - Atrens, D M
AU  - Atrens DM
FAU - Christie, M J
AU  - Christie MJ
FAU - Jackson, D M
AU  - Jackson DM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Dopamine D2 Receptor Antagonists)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Salicylamides)
RN  - 430K3SOZ7G (Raclopride)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - J6292F8L3D (Haloperidol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Benzazepines/pharmacology
MH  - Dextroamphetamine/*pharmacology
MH  - *Dopamine Antagonists
MH  - Dopamine D2 Receptor Antagonists
MH  - Haloperidol/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Raclopride
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Dopamine D1/antagonists & inhibitors
MH  - Salicylamides/pharmacology
MH  - Taste/*drug effects
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0091-3057(94)90025-6 [pii]
AID - 10.1016/0091-3057(94)90025-6 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1994 Feb;47(2):369-74. doi: 
      10.1016/0091-3057(94)90025-6.