PMID- 7910276
OWN - NLM
STAT- MEDLINE
DCOM- 19940616
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 343
IP  - 8908
DP  - 1994 May 21
TI  - Chronic parvovirus B19 infection and systemic necrotising vasculitis: 
      opportunistic infection or aetiological agent?
PG  - 1255-8
AB  - We describe three patients who had infection with human parvovirus B19 in 
      association with new-onset systemic necrotising vasculitis syndromes, two with 
      features of polyarteritis nodosa and one with features of Wegener's 
      granulomatosis. Chronic B19 infection, lasting 5 months to more than 3 years, was 
      shown by enzyme immunoassay for IgG and IgM antibodies to B19 and polymerase 
      chain reaction for B19 DNA in serum and tissue samples. The patients had atypical 
      serological responses to the B19 infection, although none had a recognisable 
      immunodeficiency disorder. Treatment with corticosteroids and cyclophosphamide 
      did not control vasculitis. Intravenous immunoglobulin (IVIG) therapy led to 
      rapid improvement of the systemic vascultis manifestations, clearing of the 
      chronic parvovirus infection, and long-term remission. These observations suggest 
      an aetiological relation between parvovirus B19 infection and systemic 
      necrotising vasculitis in these patients and indicate a potentially curative role 
      for IVIG in such disorders.
FAU - Finkel, T H
AU  - Finkel TH
AD  - Department of Pediatrics, National Jewish Center for Immunology and Respiratory 
      Medicine, Denver, Colorado 80206.
FAU - Torok, T J
AU  - Torok TJ
FAU - Ferguson, P J
AU  - Ferguson PJ
FAU - Durigon, E L
AU  - Durigon EL
FAU - Zaki, S R
AU  - Zaki SR
FAU - Leung, D Y
AU  - Leung DY
FAU - Harbeck, R J
AU  - Harbeck RJ
FAU - Gelfand, E W
AU  - Gelfand EW
FAU - Saulsbury, F T
AU  - Saulsbury FT
FAU - Hollister, J R
AU  - Hollister JR
AU  - et al.
LA  - eng
GR  - HL37260/HL/NHLBI NIH HHS/United States
GR  - R01 AI29704/AI/NIAID NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
CIN - Lancet. 1994 Jul 23;344(8917):263-4. PMID: 7913176
MH  - Adolescent
MH  - Base Sequence
MH  - Child, Preschool
MH  - Chronic Disease
MH  - DNA Primers
MH  - DNA, Viral/analysis
MH  - Erythema Infectiosum/*complications/therapy
MH  - Female
MH  - Granulomatosis with Polyangiitis/immunology/*microbiology/therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Male
MH  - Molecular Sequence Data
MH  - Parvovirus B19, Human/genetics/immunology/*isolation & purification
MH  - Polyarteritis Nodosa/immunology/*microbiology/therapy
EDAT- 1994/05/21 00:00
MHDA- 1994/05/21 00:01
CRDT- 1994/05/21 00:00
PHST- 1994/05/21 00:00 [pubmed]
PHST- 1994/05/21 00:01 [medline]
PHST- 1994/05/21 00:00 [entrez]
AID - S0140-6736(94)92152-0 [pii]
AID - 10.1016/s0140-6736(94)92152-0 [doi]
PST - ppublish
SO  - Lancet. 1994 May 21;343(8908):1255-8. doi: 10.1016/s0140-6736(94)92152-0.