PMID- 7910837
OWN - NLM
STAT- MEDLINE
DCOM- 19940630
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 169
IP  - 6
DP  - 1994 Jun
TI  - Human herpesvirus 6 DNA in blood cells of human immunodeficiency virus-infected 
      men: correlation of high levels with high CD4 cell counts.
PG  - 1342-5
AB  - The relationship between human herpesvirus 6 (HHV-6) and the progression of human 
      immunodeficiency virus type 1 (HIV-1) infection to AIDS was evaluated using the 
      polymerase chain reaction to quantitate HHV-6 genome equivalents in peripheral 
      blood mononuclear cells (PBMC) and saliva of 32 HIV-1-seropositive men. Unlike 
      other herpesviruses, HHV-6 was found with higher frequency and in higher copy 
      numbers of HIV-infected men with high rather than low CD4 cell counts. Among 
      subjects with > 400 CD4 cells/mL, 100% had detectable HHV-6 genomes in PBMC 
      compared with 57.9% of subjects with < 400 CD4 cells/mL (P < .05). There was no 
      significant correlation between HHV-6 antibody titer or number of amplifiable 
      copies of HHV-6 DNA in saliva and stage of HIV disease or CD4 cell number.
FAU - Fairfax, M R
AU  - Fairfax MR
AD  - Department of Laboratory Medicine, University of Washington School of Medicine, 
      Seattle 98144.
FAU - Schacker, T
AU  - Schacker T
FAU - Cone, R W
AU  - Cone RW
FAU - Collier, A C
AU  - Collier AC
FAU - Corey, L
AU  - Corey L
LA  - eng
GR  - AI-07044/AI/NIAID NIH HHS/United States
GR  - AI-27757/AI/NIAID NIH HHS/United States
GR  - RR-0037/RR/NCRR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/immunology/*microbiology
MH  - Adult
MH  - CD4-Positive T-Lymphocytes/cytology/*immunology
MH  - DNA, Viral/*blood
MH  - Herpesviridae Infections/*complications/microbiology
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1093/infdis/169.6.1342 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Jun;169(6):1342-5. doi: 10.1093/infdis/169.6.1342.