PMID- 7911745
OWN - NLM
STAT- MEDLINE
DCOM- 19940720
LR  - 20190830
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 78
IP  - 1
DP  - 1994 Mar 18
TI  - In vitro release of [3H]5-hydroxytryptamine from fetal and maternal brain by 
      drugs of abuse.
PG  - 142-6
AB  - Cortical synaptosomes were prepared from pregnant dams (GD-17) and rat fetuses 
      (ED-17), loaded with [3H]5-HT and assayed to evaluate release mediated by cocaine 
      (COC), fenfluramine (FEN) and 3,4-methylenedioxymethamphetamine (MDMA). COC and 
      FEN elicited a high-affinity (10(-9) M) release response in fetal tissue which 
      was not apparent in the dam. MDMA-induced release was similar in magnitude in 
      both tissue types. Consequently, the release of 5-HT from developing neurons may 
      be one mechanism by which COC and FEN elicit their teratogenetic effects in 
      utero.
FAU - Kramer, K
AU  - Kramer K
AD  - Department of Psychiatry, State University of New York at Stony Brook 11794.
FAU - Azmitia, E C
AU  - Azmitia EC
FAU - Whitaker-Azmitia, P M
AU  - Whitaker-Azmitia PM
LA  - eng
GR  - NIDA 271-90-7403/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Designer Drugs)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 660YQ98I10 (Potassium Chloride)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/pharmacokinetics/pharmacology
MH  - Animals
MH  - Brain/*embryology
MH  - Brain Chemistry/*drug effects
MH  - Cocaine/pharmacokinetics/pharmacology
MH  - Designer Drugs/pharmacokinetics/pharmacology
MH  - Female
MH  - Fenfluramine/pharmacokinetics/pharmacology
MH  - In Vitro Techniques
MH  - Maternal-Fetal Exchange
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Potassium Chloride/pharmacology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Substance-Related Disorders/*metabolism
MH  - Synaptosomes/drug effects/metabolism
EDAT- 1994/03/18 00:00
MHDA- 1994/03/18 00:01
CRDT- 1994/03/18 00:00
PHST- 1994/03/18 00:00 [pubmed]
PHST- 1994/03/18 00:01 [medline]
PHST- 1994/03/18 00:00 [entrez]
AID - 0165-3806(94)90019-1 [pii]
AID - 10.1016/0165-3806(94)90019-1 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1994 Mar 18;78(1):142-6. doi: 
      10.1016/0165-3806(94)90019-1.