PMID- 7912130
OWN - NLM
STAT- MEDLINE
DCOM- 19940728
LR  - 20190512
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 3
IP  - 3
DP  - 1994 Mar
TI  - Isolation and characterization of a novel gene encoding nuclear protein at a 
      locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).
PG  - 465-70
AB  - To identify a gene responsible for multiple endocrine neoplasia type 1 (MEN1), we 
      attempted to isolate potentially transcribable fragments from cosmid clones 
      derived from a region on chromosome 11q13 where genetic linkage studies and 
      analyses of loss of heterozygosity in MEN1-associated tumors have localized the 
      MEN1 gene. By an exon-amplification method, we recovered three exon-like 
      sequences from one of these clones, cCI11-367, and using these sequences as 
      probes we were able to isolate new clones from cerebrum, cerebellum, and 
      fetal-liver cDNA libraries. Sequence analysis of these cDNA clones revealed that 
      the transcribed gene, designated ZFM1, encodes a novel 623-amino-acid protein 
      containing domains with interesting structural properties including a nuclear 
      transport domain, a metal binding motif, and glutamine- and proline-rich regions. 
      Analysis by the reverse-transcriptase polymerase chain reaction (RT-PCR) 
      indicated that this gene is expressed in various tissues including endocrine 
      organs such as thyroid gland, pancreas, adrenal gland, and ovary. These data 
      suggest that ZFM1 might be a candidate for mutations that cause MEN1.
FAU - Toda, T
AU  - Toda T
AD  - Department of Biochemistry, Cancer Institute, Tokyo, Japan.
FAU - Iida, A
AU  - Iida A
FAU - Miwa, T
AU  - Miwa T
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Imai, T
AU  - Imai T
LA  - eng
SI  - GENBANK/D26120
SI  - GENBANK/D26121
SI  - GENBANK/D26122
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA Splicing Factors)
RN  - 0 (SF1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
GS  - MEN1
GS  - ZFM1
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Carrier Proteins/*genetics
MH  - Cell Line
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - *DNA-Binding Proteins
MH  - Exons
MH  - *Genetic Linkage
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Nuclear Proteins/*genetics
MH  - Polymerase Chain Reaction
MH  - RNA Splicing Factors
MH  - Sequence Homology, Amino Acid
MH  - *Transcription Factors
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1093/hmg/3.3.465 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1994 Mar;3(3):465-70. doi: 10.1093/hmg/3.3.465.