PMID- 7912508
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 106
IP  - 1
DP  - 1994 Mar
TI  - Lipoprotein, lecithin:cholesterol acyl transferase and acetyl CoA carboxylase in 
      stroke-prone spontaneously hypertensive rats fed a diet high in eicosapentaenoic 
      acid.
PG  - 21-8
AB  - To investigate the effect of dietary eicosapentaenoic acid (EPA) on plasma 
      lipoprotein levels, lecithin:cholesterol acyltransferase (LCAT) activity and 
      liver acetyl CoA carboxylase activity, highly concentrated EPA (78%) purified 
      from sardine oil was fed to stroke-prone spontaneously hypertensive rats (SHRSP) 
      for 30 days. Significantly (P < 0.05) lower systolic blood pressure and plasma 
      total cholesterol were observed in rats fed an EPA diet. In addition, higher HDL 
      cholesterol and lower VLDL cholesterol levels were found in rats fed the EPA diet 
      as compared with rats fed the control diet. However, no significant change of 
      plasma LDL cholesterol was observed in rats between the two dietary groups. EPA 
      supplementation increased the activity of plasma LCAT in rats. In addition, rats 
      fed an EPA diet had lower liver total lipids and adipose tissue weights. However, 
      higher liver acetyl CoA carboxylase activity was observed in rats fed the EPA 
      diet. Results from the present study suggest that dietary EPA might stimulate the 
      plasma lipoprotein metabolism and also alter lipogenesis in the liver of SHRSP 
      rats.
FAU - Chiang, M T
AU  - Chiang MT
AD  - Department of Applied Biochemistry, Faculty of Agriculture, Tohoku University, 
      Sendai, Japan.
FAU - Otomo, M I
AU  - Otomo MI
FAU - Ito, H
AU  - Ito H
FAU - Furukawa, Y
AU  - Furukawa Y
FAU - Kimura, S
AU  - Kimura S
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Lipoproteins)
RN  - 54397-85-2 (Thromboxane B2)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
RN  - EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase)
RN  - EC 6.4.1.2 (Acetyl-CoA Carboxylase)
SB  - IM
MH  - Acetyl-CoA Carboxylase/*metabolism
MH  - Administration, Oral
MH  - Animal Feed
MH  - Animals
MH  - Cerebrovascular Disorders/enzymology/*metabolism
MH  - Eicosapentaenoic Acid/administration & dosage/*pharmacology
MH  - Hypertension/enzymology/*metabolism
MH  - Lipoproteins/*blood
MH  - Liver/drug effects/enzymology
MH  - Organ Size/drug effects
MH  - Phosphatidylcholine-Sterol O-Acyltransferase/*blood
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Thromboxane B2/blood
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 0021-9150(94)90079-5 [pii]
AID - 10.1016/0021-9150(94)90079-5 [doi]
PST - ppublish
SO  - Atherosclerosis. 1994 Mar;106(1):21-8. doi: 10.1016/0021-9150(94)90079-5.