PMID- 7913870
OWN - NLM
STAT- MEDLINE
DCOM- 19940830
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 34
IP  - 2
DP  - 1994
TI  - Effects of designer drugs on the chicken embryo and 1-day-old chicken.
PG  - 143-50
AB  - The present study was conducted to examine the effects of d-amphetamine and the 
      designer drugs 3,4-methylenedioxymethamphetamine (MDMA), 
      N-methyl-3,4-methylenedioxyphenyl-3-butamine (HMDMA), 
      3,4-methylenedioxyphenyl-2-butanamine (BDB), 
      3,4-methylenedioxyphenyl-1-ethanamine (MDM1EA) in the chick embryo and the young 
      chicken. HMDMA and MDM1EA had no effect on motility on day 14 of embryogenesis, 
      while MDMA, BDB, and d-amphetamine decreased embryonic motility at one or more 
      doses. On day 1 posthatch, chickens were challenged with cumulative injections of 
      water or the same drug that they had received in ova. With the exception of 
      MDM1EA, all of the drugs produced effects such as distress vocalization, wing 
      extension, tremor, flat body posture, bursting forward movements, loss of 
      righting reflex, and convulsant-like kicking. Pretreatment with drug in ova 
      resulted in tolerance to certain drug effects and supersensitivity to other drug 
      effects. Furthermore, BDB significantly decreased hatchability, MDM1EA decreased 
      body weight, and HMDMA decreased liver weight. Further studies are needed to 
      determine the mechanism(s) of toxicity in this species.
FAU - Bronson, M E
AU  - Bronson ME
AD  - Auburn University School of Pharmacy, Department of Pharmacal Sciences, Auburn 
      University, AL 36849-5503.
FAU - Jiang, W
AU  - Jiang W
FAU - Clark, C R
AU  - Clark CR
FAU - DeRuiter, J
AU  - DeRuiter J
LA  - eng
GR  - NIDA DA 06637/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Designer Drugs)
RN  - 059QF0KO0R (Water)
RN  - 107447-03-0 (1-(3,4-methylenedioxyphenyl)-2-butanamine)
RN  - 121734-64-3 (3,4-methylenedioxyphenyl-1-ethanamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 92279-87-3 (N-methyl-3,4-methylenedioxyphenylisobutylamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Chick Embryo
MH  - Chickens
MH  - Designer Drugs/*pharmacology
MH  - Dextroamphetamine/pharmacology
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - Models, Biological
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Water
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0361-9230(94)90011-6 [pii]
AID - 10.1016/0361-9230(94)90011-6 [doi]
PST - ppublish
SO  - Brain Res Bull. 1994;34(2):143-50. doi: 10.1016/0361-9230(94)90011-6.