PMID- 7915216
OWN - NLM
STAT- MEDLINE
DCOM- 19940929
LR  - 20190722
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 40
IP  - 9
DP  - 1994 Sep
TI  - Microwave-induced rapid preparation of fluoro-derivatives of amphetamine, 
      methamphetamine, and 3,4-methylenedioxymethamphetamine for GC-MS confirmation 
      assays.
PG  - 1703-6
AB  - We prepared trifluoroacetyl, pentafluoropropyl, and heptafluorobutyl derivatives 
      of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in 
      45 s, 1 min, and 6 min, respectively, by using microwave irradiation. 
      Conventional techniques require heating the reaction mixture for 15 min at 40 
      degrees C for trifluoroacetyl derivatives, 15 min at 75 degrees C for 
      pentafluoropropyl derivatives, and 40 min at 60 degrees C for heptafluorobutyl 
      derivatives. The mass-spectral fragmentation patterns and the gas-chromatographic 
      retention times of the derivatives obtained by both microwave irradiation and 
      conventional heating were similar. Perfluorooctanoyl derivatives of amphetamine 
      can be prepared quantitatively by either heating the reaction mixture for 30 min 
      at 60 degrees C or by 1 min of microwave irradiation. Conversion of 
      methamphetamine and MDMA to the corresponding perfluorooctanoyl derivatives was 
      not quantitative by either technique, although the yield of the derivative in the 
      conventional technique was much higher.
FAU - Thompson, W C
AU  - Thompson WC
AD  - Department of Pathology, University of New Mexico School of Medicine, Albuquerque 
      87106.
FAU - Dasgupta, A
AU  - Dasgupta A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (Designer Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - C045TQL4WP (Phentermine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/analysis/chemistry/urine
MH  - Amphetamine/*analysis/chemistry/urine
MH  - Calibration
MH  - Designer Drugs/*analysis/chemistry
MH  - Fluorides/chemistry
MH  - Gas Chromatography-Mass Spectrometry
MH  - Methamphetamine/*analysis/chemistry/urine
MH  - *Microwaves
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Phentermine/analysis
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
PST - ppublish
SO  - Clin Chem. 1994 Sep;40(9):1703-6.