PMID- 7915416
OWN - NLM
STAT- MEDLINE
DCOM- 19940923
LR  - 20191101
IS  - 0172-8113 (Print)
IS  - 0172-8113 (Linking)
VI  - 15
IP  - 3
DP  - 1994 Jun
TI  - [Multiple endocrine neoplasia type 1 (MEN 1). Molecular genetics, morphology and 
      prognosis].
PG  - 150-7
AB  - The syndrome of multiple endocrine neoplasia type 1 (MEN 1) is an autosomal 
      dominant tumour disease of the neuroendocrine system with manifestations in the 
      parathyroids, pancreas, duodenum and pituitary gland and rarely also in the 
      stomach and thymus. Recently, the MEN 1 gene locus has been mapped to the long 
      arm of chromosome 11. This gene most likely belongs to the tumour suppressor 
      genes, the allelic loss of which causes tumour development. The pancreatic and 
      duodenal tumours may metastasize, but usually have a low malignant potential. 
      Clinically, most MEN 1 patients present between the age of 20 and 35 with 
      hyperparathyroidism and/or Zollinger-Ellison syndrome.
FAU - Schroder, S
AU  - Schroder S
AD  - Department Pathologie, Universitat Zurich.
FAU - Padberg, B
AU  - Padberg B
FAU - Capella, C
AU  - Capella C
FAU - Frilling, A
AU  - Frilling A
FAU - Kloppel, G
AU  - Kloppel G
FAU - Heitz, P U
AU  - Heitz PU
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Multiple endokrine Neoplasie Typ 1 (MEN 1). Molekulargenetik, Morphologie und 
      Prognose.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
SB  - IM
MH  - Adrenal Glands/pathology
MH  - Adult
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 11
MH  - Female
MH  - Genes, Tumor Suppressor/genetics
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia/genetics/*pathology
MH  - Mutation
MH  - Pancreas/pathology
MH  - Parathyroid Glands/pathology
MH  - Pituitary Gland/pathology
MH  - Prognosis
MH  - Stomach/pathology
RF  - 87
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1007/s002920050038 [doi]
PST - ppublish
SO  - Pathologe. 1994 Jun;15(3):150-7. doi: 10.1007/s002920050038.