PMID- 7915525
OWN - NLM
STAT- MEDLINE
DCOM- 19940930
LR  - 20190920
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 26
IP  - 3
DP  - 1994 Jun
TI  - Family screening in multiple endocrine neoplasia type 1 (MEN 1).
PG  - 191-8
AB  - Multiple endocrine neoplasia type 1 is an autosomal dominantly inherited disorder 
      predisposing to development of neoplastic lesions in the parathyroid glands, the 
      neuro-endocrine pancreas-duodenum and the anterior pituitary. The genetic defect 
      was mapped to the centromeric region of the long arm of chromosome 11, based on 
      studies of somatic deletions in MEN 1-associated tumours and linkage analysis in 
      affected families. Combined family and tumour analyses have shown that 
      tumourigenesis in MEN 1 involves loss of the wild type chromosome, indicating 
      that the putative MEN 1 gene is a tumour suppressor gene. Based on results from 
      linkage analysis in more than 40 MEN 1 families, presymptomatic testing for MEN 1 
      using DNA polymorphisms can now be performed with high accuracy. Hence, 
      biochemical screening programmes can focus on individuals at risk, in order to 
      identify early signs of tumour development.
FAU - Larsson, C
AU  - Larsson C
AD  - Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
FAU - Nordenskjold, M
AU  - Nordenskjold M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
GS  - MEN 1
MH  - Chromosomes, Human, Pair 11
MH  - DNA, Neoplasm/genetics
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - Multiple Endocrine Neoplasia/diagnosis/*genetics
MH  - Pedigree
MH  - Polymorphism, Genetic
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.3109/07853899409147889 [doi]
PST - ppublish
SO  - Ann Med. 1994 Jun;26(3):191-8. doi: 10.3109/07853899409147889.