PMID- 7916047
OWN - NLM
STAT- MEDLINE
DCOM- 19941013
LR  - 20190710
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 46
IP  - 5
DP  - 1994 May
TI  - Evidence for a dopaminergic involvement in the renal action of centrally 
      administered JA116a, a novel compound with possible dopaminergic activity, in 
      rats.
PG  - 397-9
AB  - Intracerebroventricular (i.c.v.) administration of JA116a, induces an increase in 
      urinary volume and sodium excretion in conscious male hydrated rats. The 
      involvement of brain dopaminergic neurons in the JA116a renal action was 
      investigated. Diuretic and natriuretic action of JA116a was blocked by 
      haloperidol pretreatment. The renal effect was prevented by selective 
      dopaminergic neuron, denervation by i.c.v. administration of 6-hydroxydopamine in 
      combination with desmethylimipramine. Our results suggest that JA116a acts 
      centrally, at least in part, via an interaction with endogenous dopamine neurons.
FAU - Orfila, G L
AU  - Orfila GL
AD  - Faculty of Pharmacy, Department of Biological Sciences, Universidad Central de 
      Venezuela, Caracas.
FAU - Angel, J
AU  - Angel J
FAU - Torres, M
AU  - Torres M
FAU - Barbella, Y
AU  - Barbella Y
FAU - Israel, A
AU  - Israel A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (6,7,8,8a-tetrahydro-1-aminoacenaphthylene)
RN  - 0 (Acenaphthenes)
RN  - 0 (Diuretics)
RN  - 0 (Dopamine Agents)
RN  - 0 (Receptors, Dopamine)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - J6292F8L3D (Haloperidol)
RN  - RWP5GA015D (Potassium)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - Acenaphthenes/administration & dosage/*pharmacology
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Desipramine/pharmacology
MH  - Diuretics/pharmacology
MH  - Dopamine Agents/administration & dosage/*pharmacology
MH  - Haloperidol/pharmacology
MH  - Injections, Intraventricular
MH  - Kidney/*drug effects
MH  - Male
MH  - Molecular Structure
MH  - Natriuresis/drug effects
MH  - Neurons/drug effects/metabolism
MH  - Oxidopamine/pharmacology
MH  - Potassium/urine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine/drug effects
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1111/j.2042-7158.1994.tb03825.x [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 1994 May;46(5):397-9. doi: 10.1111/j.2042-7158.1994.tb03825.x.