PMID- 7916156
OWN - NLM
STAT- MEDLINE
DCOM- 19941011
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 56
IP  - 1
DP  - 1994 Jul
TI  - Metabolic and thermoregulatory responses of the rat maintained in acrylic or 
      wire-screen cages: implications for pharmacological studies.
PG  - 73-9
AB  - Because of differences in thermal conductivity, it is likely that a rodent's 
      thermoregulatory requirements and their response to drugs and other stimuli will 
      vary in metal and acrylic cages. To address these issues, thermoregulatory 
      responses were measured in rats housed in an environmental chamber with a floor 
      made of either solid metal (aluminum) or acrylic materials (Plexiglas). Metabolic 
      rate (M), evaporative water loss (E), thermal conductance (C), and tail skin 
      (Tsk) and core temperature (Tc) were measured at ambient temperatures (Ta) of 10, 
      20, 28, 30, 32, and 34 degrees C. These thermoregulatory variables were 
      essentially unaffected by floor type at Tas of 20 and 28 degrees C. The acrylic 
      floor showed greater increases in M, E, Tc, and Tsk, but a smaller elevation in C 
      as Ta increased from 28 to 34 degrees C. At a Ta of 10 degrees C, rats on the 
      acrylic floor had a smaller M compared to that measured on the metal floor. Rats 
      were then injected with saline or 30 mg/kg (SC) of 
      3,4-methylenedioxymethamphetamine (MDMA) and placed in an acrylic cage with wood 
      chip bedding or a wire-screen cage at a Ta of 20 degrees C. The MDMA caused Tc to 
      increase > 2.0 degrees C in rats in the acrylic cage but had no effect on Tc of 
      rats in the wire-screen cage. The marked effect of cage type on basal 
      thermoregulatory processes and thermogenic response to MDMA should be useful in 
      the design and interpretation of many pharmacological studies.
FAU - Gordon, C J
AU  - Gordon CJ
AD  - Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle 
      Park, NC 27711.
FAU - Fogelson, L
AU  - Fogelson L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Methylmethacrylates)
RN  - 12597-68-1 (Stainless Steel)
RN  - 196OC77688 (Methylmethacrylate)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Acclimatization/*drug effects
MH  - Animals
MH  - Body Temperature Regulation/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Energy Metabolism/*drug effects
MH  - *Housing, Animal
MH  - Male
MH  - Methylmethacrylate
MH  - *Methylmethacrylates
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - *Stainless Steel
MH  - Water Loss, Insensible/drug effects
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 0031-9384(94)90263-1 [pii]
AID - 10.1016/0031-9384(94)90263-1 [doi]
PST - ppublish
SO  - Physiol Behav. 1994 Jul;56(1):73-9. doi: 10.1016/0031-9384(94)90263-1.