PMID- 7916481
OWN - NLM
STAT- MEDLINE
DCOM- 19941019
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 265
IP  - 5180
DP  - 1994 Sep 23
TI  - Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma 
      delta T cells.
PG  - 1869-71
AB  - Indirect evidence implicates gamma delta T cells in the cross-regulation of CD4 
      alpha beta T cell responses. Adoptive transfer of small numbers of gamma delta T 
      cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent 
      immunoglobulin E (IgE) antibody production without affecting parallel IgG 
      responses. Challenge of these gamma delta T cells in vitro with specific antigen 
      resulted in production of high levels of interferon gamma. The effects of the 
      gamma delta T cells may be mediated by direct inhibition of OVA-specific CD4+ TH2 
      cell proliferation or selection for specific CD4 TH2 cells.
FAU - McMenamin, C
AU  - McMenamin C
AD  - Division of Cell Biology, Institute for Child Health Research, West Perth, 
      Western Australia.
FAU - Pimm, C
AU  - Pimm C
FAU - McKersey, M
AU  - McKersey M
FAU - Holt, P G
AU  - Holt PG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-2)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (Transforming Growth Factor beta)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Dose-Response Relationship, Immunologic
MH  - *Immune Tolerance
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunotherapy, Adoptive
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-2/biosynthesis
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology
MH  - Receptors, Antigen, T-Cell, gamma-delta/*immunology
MH  - T-Lymphocyte Subsets/*immunology
MH  - Transforming Growth Factor beta/biosynthesis
EDAT- 1994/09/23 00:00
MHDA- 1994/09/23 00:01
CRDT- 1994/09/23 00:00
PHST- 1994/09/23 00:00 [pubmed]
PHST- 1994/09/23 00:01 [medline]
PHST- 1994/09/23 00:00 [entrez]
AID - 10.1126/science.7916481 [doi]
PST - ppublish
SO  - Science. 1994 Sep 23;265(5180):1869-71. doi: 10.1126/science.7916481.