PMID- 7916987
OWN - NLM
STAT- MEDLINE
DCOM- 19941102
LR  - 20191023
IS  - 0899-1987 (Print)
IS  - 0899-1987 (Linking)
VI  - 11
IP  - 1
DP  - 1994 Sep
TI  - Increased expression of matrix metalloproteinase-3 (stromelysin-1) in cultured 
      fibroblasts and basal cell carcinomas of nevoid basal cell carcinoma syndrome.
PG  - 29-33
AB  - Nevoid basal cell carcinoma syndrome (NBCCS), an autosomal dominant disorder, is 
      characterized by the development of numerous cutaneous basal cell carcinomas 
      (BCCs). To better characterize this disorder, we examined the expression of 
      matrix metalloproteinase-3 (MMP-3; also known as stromelysin-1) in BCC tumor 
      specimens, adjacent normal skin, and fibroblasts isolated from the 
      normal-appearing skin of NBCCS patients. Three of three BCC tumors obtained from 
      NBCCS patients overexpressed MMP-3 mRNA. In contrast, only 25% of BCC specimens 
      in patients without NBCCS demonstrated overexpression of MMP-3 mRNA. Moreover, 
      fibroblasts isolated and cultured from all nine uninvolved skin specimens of 
      NBCCS patients overexpressed MMP-3 mRNA. MMP-3 mRNA was not detected or was 
      detected at very low levels in normal skin and fibroblast cultures isolated from 
      normal skin in nonsyndrome patients.
FAU - Majmudar, G
AU  - Majmudar G
AD  - Department of Dermatology, University of Michigan, Ann Arbor 48109.
FAU - Nelson, B R
AU  - Nelson BR
FAU - Jensen, T C
AU  - Jensen TC
FAU - Johnson, T M
AU  - Johnson TM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Carcinog
JT  - Molecular carcinogenesis
JID - 8811105
RN  - 0 (Carrier Proteins)
RN  - 0 (RNA, Neoplasm)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
RN  - EC 5.1.1.- (Amino Acid Isomerases)
RN  - EC 5.2.1.8 (Peptidylprolyl Isomerase)
SB  - IM
MH  - Amino Acid Isomerases/metabolism
MH  - Basal Cell Nevus Syndrome/*metabolism
MH  - Carcinoma, Basal Cell/*metabolism
MH  - Carrier Proteins/metabolism
MH  - Collagenases/metabolism
MH  - Fibroblasts/metabolism
MH  - Gene Expression
MH  - Humans
MH  - Matrix Metalloproteinase 1
MH  - Matrix Metalloproteinase 3
MH  - Metalloendopeptidases/genetics/*metabolism
MH  - Peptidylprolyl Isomerase
MH  - RNA, Neoplasm/genetics
MH  - Skin/metabolism
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1002/mc.2940110106 [doi]
PST - ppublish
SO  - Mol Carcinog. 1994 Sep;11(1):29-33. doi: 10.1002/mc.2940110106.