PMID- 7917090
OWN - NLM
STAT- MEDLINE
DCOM- 19941102
LR  - 20190914
IS  - 0268-8697 (Print)
IS  - 0268-8697 (Linking)
VI  - 8
IP  - 2
DP  - 1994
TI  - Chlorpromazine in combination with nitrosourea inhibits experimental glioma 
      growth.
PG  - 187-92
AB  - Modern cancer therapy has improved the prognosis for several tumour types. This, 
      however, does not apply to the largest group of brain tumours, the malignant 
      astrocytomas grades III-IV. Hence, there is need for new ideas to improve 
      treatment. Ca2+ and the Ca(2+)-binding protein calmodulin have been shown to be 
      involved in the processes conferring stability to DNA in proliferating neoplastic 
      cells. We have combined the calmodulin-inhibiting neuroleptic drug chlorpromazine 
      (CPZ), with the anti-neoplastic drug 1,3-bis(2-chloroethyl-1)-nitrosourea (BCNU) 
      in a treatment regime for rats with glioma cells implanted in the brain. A highly 
      significant inhibiting effect upon the tumour growth was noticed, not by CPZ or 
      BCNU as single drugs, but with their combination.
FAU - Aas, A T
AU  - Aas AT
AD  - Department of Neurosurgery, Lund University Hospital, Sweden.
FAU - Brun, A
AU  - Brun A
FAU - Pero, R W
AU  - Pero RW
FAU - Salford, L G
AU  - Salford LG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
RN  - 0 (Calmodulin)
RN  - U42B7VYA4P (Chlorpromazine)
RN  - U68WG3173Y (Carmustine)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain Neoplasms/*pathology
MH  - Calmodulin/antagonists & inhibitors/physiology
MH  - Carmustine/*pharmacology/toxicity
MH  - Cell Division/*drug effects/physiology
MH  - Chlorpromazine/*pharmacology/toxicity
MH  - Drug Synergism
MH  - Female
MH  - Glioblastoma/*pathology
MH  - Male
MH  - Neoplasm Transplantation
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.3109/02688699409027965 [doi]
PST - ppublish
SO  - Br J Neurosurg. 1994;8(2):187-92. doi: 10.3109/02688699409027965.