PMID- 7917686
OWN - NLM
STAT- MEDLINE
DCOM- 19941101
LR  - 20190503
IS  - 0007-0769 (Print)
IS  - 0007-0769 (Linking)
VI  - 72
IP  - 2
DP  - 1994 Aug
TI  - Increased alveolar/capillary membrane resistance to gas transfer in patients with 
      chronic heart failure.
PG  - 140-4
AB  - OBJECTIVE: To investigate pulmonary diffusive resistance to gas exchange in 
      patients with heart failure and healthy volunteers, assessing the relative 
      contributions of the alveolar/capillary membrane and pulmonary capillary blood. 
      SETTING: Hospital outpatient department and pulmonary function laboratory. 
      PATIENTS: 38 patients (mean age 60) receiving treatment with loop diuretics and 
      angiotensin converting enzyme inhibitors for stable symptomatic heart failure of 
      > 6 months duration (New York Heart Association (NYHA) classes II and III). 
      Results were compared with those of 17 healthy volunteers (mean age 52). METHODS: 
      The alveolar/capillary membrane diffusive resistance and the pulmonary capillary 
      blood volume available for physiological gas exchange were determined by the 
      Roughton and Forster method, which measures the single breath pulmonary diffusing 
      capacity for carbon monoxide at varying alveolar oxygen concentrations. RESULTS: 
      Total pulmonary diffusive resistance was higher in patients than controls. 
      Alveolar/capillary membrane resistance formed the main component of this 
      increase, accounting for a mean (SD) of 63% (20%) and 86% (8%) of total pulmonary 
      diffusive resistance in patients in NYHA II and III classes respectively, 
      compared with 53% (10%) in controls. The pulmonary capillary blood volume was not 
      significantly different between controls and patients in NYHA class II (66 (18) 
      ml v 61 (18) ml), but was increased in those in NYHA class III (95(46) ml, P < 
      0.05). CONCLUSION: This study confirmed impairment of pulmonary diffusion at rest 
      in patients with chronic heart failure and identified impaired alveolar/capillary 
      membrane function as the main factor responsible.
FAU - Puri, S
AU  - Puri S
AD  - Department of Medicine (Clinical Cardiology), Royal Postgraduate Medical School, 
      Hammersmith Hospital, London.
FAU - Baker, B L
AU  - Baker BL
FAU - Oakley, C M
AU  - Oakley CM
FAU - Hughes, J M
AU  - Hughes JM
FAU - Cleland, J G
AU  - Cleland JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br Heart J
JT  - British heart journal
JID - 0370634
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood-Air Barrier/*physiology
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pulmonary Diffusing Capacity
MH  - Reproducibility of Results
PMC - PMC1025477
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
PMCR- 1994/08/01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
PHST- 1994/08/01 00:00 [pmc-release]
AID - 10.1136/hrt.72.2.140 [doi]
PST - ppublish
SO  - Br Heart J. 1994 Aug;72(2):140-4. doi: 10.1136/hrt.72.2.140.