PMID- 7917761
OWN - NLM
STAT- MEDLINE
DCOM- 19941107
LR  - 20061115
IS  - 0393-9340 (Print)
IS  - 0393-9340 (Linking)
VI  - 9
IP  - 2
DP  - 1994 Apr-Jun
TI  - [Light chain deposition disease].
PG  - 100-4
AB  - We report the case of a rather rare form of K-light chain deposition disease 
      (LCDD) in a 61-year-old man with hypertension and rapidly progressing 
      nephropathy. Laboratory findings prompted suspicion of the diagnosis which was 
      confirmed by light-microscopic and immunofluorescent studies of samples taken by 
      percutaneous renal and liver biopsy. Hepatic and urinary K-light chains were 
      present; no circulating light chains were detected. Bone marrow examination 
      evidenced mild infiltration of lymphoid cells, all positive for K-light chain 
      staining. Plasma cells were within normal ranges. LCDD appeared as nodular 
      glomerulosclerosis with rare crescents and extensive tubular involvement with 
      K-light chain deposits. There was no evidence of altered liver function, nor was 
      amyloid found in the bone marrow, kidney or liver. After one year of continuous 
      therapy with melphalan and prednisone, the patient's renal function has not 
      worsened. We conclude with a review of the clinical and physiopathological 
      features of the light chain subgroup of monoclonal immunoglobulin deposition 
      diseases (MIDD).
FAU - Terzani, E
AU  - Terzani E
AD  - Divisione di Medicina Interna IV, Policlinico di Careggi, Firenze.
FAU - Alterini, B
AU  - Alterini B
FAU - Doni, M
AU  - Doni M
FAU - Lampronti, V
AU  - Lampronti V
FAU - Lusini, C
AU  - Lusini C
FAU - Fazzini, G
AU  - Fazzini G
LA  - ita
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - La malattia da deposito di catene leggere.
PL  - Italy
TA  - Ann Ital Med Int
JT  - Annali italiani di medicina interna : organo ufficiale della Societa italiana di 
      medicina interna
JID - 8806705
RN  - 0 (Immunoglobulin kappa-Chains)
SB  - IM
MH  - Glomerulonephritis, Membranoproliferative/diagnosis/immunology
MH  - Humans
MH  - Hypergammaglobulinemia/*diagnosis/immunology
MH  - *Immunoglobulin kappa-Chains/analysis
MH  - Male
MH  - Middle Aged
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
PST - ppublish
SO  - Ann Ital Med Int. 1994 Apr-Jun;9(2):100-4.