PMID- 7921225
OWN - NLM
STAT- MEDLINE
DCOM- 19941115
LR  - 20190904
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 131
IP  - 4
DP  - 1994 Oct
TI  - Changes in calciotrophic hormones and biochemical markers of bone turnover in 
      normal human pregnancy.
PG  - 369-74
AB  - Plasma concentrations of parathyroid hormone-related protein (PTHrP), parathyroid 
      hormone, alkaline phosphatase, osteocalcin and albumin-adjusted calcium were 
      measured along with nephrogenous cyclic adenosine monophosphate (NcAMP) in 10 
      normal women longitudinally through pregnancy. In addition, an assessment of bone 
      resorption was made in these same subjects by the measurement in true fasting 
      urine specimens of the calcium/creatinine ratio (Ca/Cr), 
      hydroxyproline/creatinine ratio (HP/Cr), pyridinoline/creatinine ratio (Pyr/Cr) 
      and deoxypyridinoline/creatine ratio (Dpyr/Cr). The PTHrP level rose through 
      pregnancy from (mean +/- SEM) 0.8 +/- 0.2 pmol/l in the first trimester to 2.7 
      +/- 0.2 pmol/l 6 weeks postpartum (p < 0.0001). Serum alkaline phosphatase rose 
      from 94 +/- 8 U/l (first trimester) to 347 +/- 25 U/l at term (p < 0.0001). A 
      significant positive correlation was evident between PTHrP and alkaline 
      phosphatase up to term (r = 0.44, p < 0.005). Parathyroid hormone concentrations 
      remained unchanged during pregnancy but rose significantly postpartum from 1.8 
      +/- 0.2 pmol/l (first trimester) to 3.1 +/- 0.5 pmol/l (p < 0.0001). Similarly, 
      osteocalcin, a marker of bone formative activity, remained unchanged through 
      pregnancy but rose significantly at 6 weeks after delivery to 0.38 +/- 0.05 
      nmol/l from 0.19 +/- 0.03 nmol/l (first trimester) (p = 0.019). No significant 
      change was noted in serum-adjusted calcium or NcAMP, either through pregnancy or 
      at the postpartum assessment. Fasting urinary Ca/Cr fell through pregnancy from 
      0.70 +/- 0.11 (first trimester) to a nadir of 0.19 +/- 0.04 6 weeks postpartum (p 
      = 0.007).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Gallacher, S J
AU  - Gallacher SJ
AD  - University Department of Medicine and Institute of Biochemistry, Glasgow Royal 
      Infirmary, UK.
FAU - Fraser, W D
AU  - Fraser WD
FAU - Owens, O J
AU  - Owens OJ
FAU - Dryburgh, F J
AU  - Dryburgh FJ
FAU - Logue, F C
AU  - Logue FC
FAU - Jenkins, A
AU  - Jenkins A
FAU - Kennedy, J
AU  - Kennedy J
FAU - Boyle, I T
AU  - Boyle IT
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Amino Acids)
RN  - 0 (PTHLH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Parathyroid Hormone-Related Protein)
RN  - 0 (Proteins)
RN  - 104982-03-8 (Osteocalcin)
RN  - 63800-01-1 (pyridinoline)
RN  - 90032-33-0 (deoxypyridinoline)
RN  - 9007-34-5 (Collagen)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alkaline Phosphatase/*blood
MH  - Amino Acids/blood/urine
MH  - Bone Resorption/urine
MH  - Bone and Bones/*metabolism
MH  - Calcium/*blood/urine
MH  - Collagen/urine
MH  - Creatinine/urine
MH  - Female
MH  - Humans
MH  - Osteocalcin/*blood
MH  - Parathyroid Hormone/*blood
MH  - Parathyroid Hormone-Related Protein
MH  - Pregnancy/*blood/*metabolism/urine
MH  - Proteins/*analysis
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1530/eje.0.1310369 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1994 Oct;131(4):369-74. doi: 10.1530/eje.0.1310369.