PMID- 7921607
OWN - NLM
STAT- MEDLINE
DCOM- 19941109
LR  - 20190512
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 112
IP  - 3
DP  - 1994 Jul
TI  - Comparison of antinociception induced by supraspinally administered L-arginine 
      and kyotorphin.
PG  - 817-22
AB  - 1. Intracerebroventricular (i.c.v.) or intracisternal (i.cist.) administration of 
      kyotorphin (KTP), an endogenous Met-enkephalin releaser, at 5 micrograms per 
      mouse, and L-arginine (L-Arg), a possible KTP precursor, at 30 micrograms per 
      mouse, elicited antinociception in mice to a similar extent, as assessed by the 
      tail-flick test. 2. Intracisternal preadministration of anti-KTP serum abolished 
      the effect of i.cist. KTP and i.c.v. or i.cist. L-Arg, but not of i.c.v. KTP. 3. 
      The antinociceptive effects of i.cist. KTP and of i.c.v. or i.cist. L-Arg 
      disappeared in reserpinized mice, whereas the effect of i.c.v. KTP was unaffected 
      by treatment of mice with reserpine. 4. Intrathecal (i.t.) phentolamine markedly 
      reduced the antinociception induced by i.cist. KTP and by i.c.v. or i.cist. 
      L-Arg, but not by i.c.v. KTP. 5. Intrathecal methysergide attenuated the 
      antinociceptive effects of i.cist. KTP, but not of i.c.v. KTP and i.c.v. or 
      i.cist. L-Arg. 6. These results suggest that the antinociception produced by 
      i.cist. KTP, but not by i.c.v. KTP, is mediated by the brainstem-spinal 
      noradrenergic and 5-hydroxytryptaminergic systems, and that L-Arg given i.c.v. or 
      i.cist. increases KTP formation in the lower brain, possibly the brainstem, 
      resulting in antinociception mediated by the descending noradrenergic system. 
      Therefore, the regional distribution of KTP receptors and KTP synthetase in the 
      brain does not appear to be common.
FAU - Kawabata, A
AU  - Kawabata A
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University, 
      Higashi-Osaka, Japan.
FAU - Manabe, S
AU  - Manabe S
FAU - Takagi, H
AU  - Takagi H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Analgesics)
RN  - 0 (Endorphins)
RN  - 02N30CW3X0 (kyotorphin)
RN  - 333DO1RDJY (Serotonin)
RN  - 8B1QWR724A (Reserpine)
RN  - 94ZLA3W45F (Arginine)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XZA9HY6Z98 (Methysergide)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Analgesics/antagonists & inhibitors/*pharmacology
MH  - Animals
MH  - Arginine/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Brain Stem/physiology
MH  - Cisterna Magna
MH  - Endorphins/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Injections
MH  - Injections, Intraventricular
MH  - Male
MH  - Methysergide/pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Norepinephrine/physiology
MH  - Pain Measurement/drug effects
MH  - Phentolamine/pharmacology
MH  - Reserpine/pharmacology
MH  - Serotonin/physiology
MH  - Spinal Cord/physiology
PMC - PMC1910193
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
PMCR- 1995/07/01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
PHST- 1995/07/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1994.tb13152.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1994 Jul;112(3):817-22. doi: 10.1111/j.1476-5381.1994.tb13152.x.