PMID- 7923081
OWN - NLM
STAT- MEDLINE
DCOM- 19941116
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 77
IP  - 1
DP  - 1994 Oct
TI  - High incidence of monosomy 18 in lymphoid malignancies that have bone marrow and 
      peripheral blood involvement.
PG  - 39-44
AB  - We studied the incidence of numerical chromosome 18 abnormalities in 107 patients 
      with lymphoid malignancies by fluorescence in situ hybridization (FISH) using a 
      directly conjugated centromeric probe for chromosome 18. Samples were obtained by 
      fine needle aspiration of diseased nodes, bone marrows or peripheral blood. 
      Monosomy 18 was more common in chronic lymphocytic leukemia (43%), small 
      lymphocytic lymphoma (28%), and follicular lymphomas (12.5%) than in diffuse 
      lymphomas (5.3%; p < 0.01). Monosomy 18 was detected in 9.7-17.1% of the cells in 
      non-Hodgkin's lymphoma (NHL) (background, 5.4%; 99% CI, 4.2%-6.6%) and in 
      8%-16.7% (median, 10%) of the cells in (CLL) (background, 3.4%; 99% CI, 
      2.5%-4.3%). All patients with monosomy 18 were found to have bone marrow 
      involvement. Of all untreated patients who had disease involving the bone marrow, 
      32% were found to have monosomy 18. Trisomy 18 was detected in 3.6%-48.2% of the 
      cells in NHL (background, 0.9%; 99% CI, 0.2%-1.6%) and was most common in diffuse 
      large-cell lymphoma (34%) and follicular lymphomas (31%). None of the patients 
      with small lymphocytic lymphoma or chronic lymphocytic leukemia had trisomy 18. 
      There was no correlation between trisomy 18 and response to treatment or clinical 
      presentation. In this study, monosomy 18 was observed frequently in patients with 
      lymphoid malignancies that involve the bone marrow and peripheral blood. Our data 
      suggest that important gene(s) located on chromosome 18 may be involved in homing 
      of the malignant lymphocytes to the bone marrow and peripheral blood.
FAU - Younes, A
AU  - Younes A
AD  - Division of Medicine, University of Texas M. D. Anderson Cancer Center, Houston 
      77030.
FAU - Jendiroba, D
AU  - Jendiroba D
FAU - Engel, H
AU  - Engel H
FAU - Escudier, S
AU  - Escudier S
FAU - Katz, R
AU  - Katz R
FAU - Rodriguez, M A
AU  - Rodriguez MA
FAU - Hill, D
AU  - Hill D
FAU - Cabanillas, F
AU  - Cabanillas F
FAU - Andreeff, M
AU  - Andreeff M
LA  - eng
GR  - CA-16672/CA/NCI NIH HHS/United States
GR  - CA-55164/CA/NCI NIH HHS/United States
GR  - CA-62595/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow/*pathology
MH  - *Chromosomes, Human, Pair 18
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/blood/*genetics/pathology
MH  - Lymphoma, Non-Hodgkin/blood/*genetics/pathology
MH  - Middle Aged
MH  - *Monosomy
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 0165-4608(94)90146-5 [pii]
AID - 10.1016/0165-4608(94)90146-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Oct;77(1):39-44. doi: 10.1016/0165-4608(94)90146-5.