PMID- 7923125
OWN - NLM
STAT- MEDLINE
DCOM- 19941103
LR  - 20111117
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 54
IP  - 19
DP  - 1994 Oct 1
TI  - A clinical and epidemiological study of human leukocyte antigen-DPB alleles in 
      Hodgkin's disease.
PG  - 5101-5
AB  - An international study to investigate the role of human leukocyte antigen 
      (HLA)-DPB alleles in Hodgkin's disease was conducted with 17 participating 
      centers in 12 countries. A total of 741 patients and 686 controls were typed 
      using polymerase chain reaction amplification of HLA-DPB alleles and subsequent 
      sequence specific oligonucleotide hybridization. The frequency of HLA-DPB1*0301 
      was found to be significantly increased in white patients, compared with 
      ethnically matched controls. In this population group, the DPB1*0301 allele is 
      associated with a relative risk of 1.95 (P < 0.01). There was also a significant 
      reduction in the frequency of HLA-DPB1*0401 in patients from Japan and Taiwan 
      (relative risk, 0.15; P < 0.01). Clinical analysis from data on 551 patients 
      demonstrated a significantly inferior remission duration in patients with 
      HLA-DPB1*0901, overall (P < 0.05), and in the Japanese and Taiwanese populations 
      (P = 0.02), where this allele is most prevalent. This analysis suggests an 
      epidemiological as well as a possible prognostic association between HLA-DPB 
      alleles and Hodgkin's disease.
FAU - Oza, A M
AU  - Oza AM
AD  - ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, United 
      Kingdom.
FAU - Tonks, S
AU  - Tonks S
FAU - Lim, J
AU  - Lim J
FAU - Fleetwood, M A
AU  - Fleetwood MA
FAU - Lister, T A
AU  - Lister TA
FAU - Bodmer, J G
AU  - Bodmer JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - *Alleles
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - Hodgkin Disease/*genetics/immunology
MH  - Humans
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1994 Oct 1;54(19):5101-5.