PMID- 7923933
OWN - NLM
STAT- MEDLINE
DCOM- 19941108
LR  - 20190821
IS  - 0090-1229 (Print)
IS  - 0090-1229 (Linking)
VI  - 73
IP  - 2
DP  - 1994 Nov
TI  - The effect of treatment with interleukin-1 and tumor necrosis factor on 
      Pseudomonas aeruginosa lung infection in a granulocytopenic mouse model.
PG  - 261-6
AB  - The efficacy of treatment with interleukin-1 beta (IL-1 beta) and tumor necrosis 
      factor-alpha (TNF alpha) on Pseudomonas aeruginosa pneumonia was evaluated in a 
      granulocytopenic mouse model. Combined intravenous administration of 2000 U IL-1 
      beta plus 2000 U TNF alpha significantly diminished mortality from aerosol 
      challenge with P. aeruginosa. Mice treated with IL-1 beta, TNF alpha, or both 
      also exhibited a significant enhancement in pulmonary clearance of P. aeruginosa. 
      Combined cytokine administration induced an increase in the pulmonary content of 
      myeloperoxidase activity. Mature leukocytes were not detected in either 
      circulation or bronchoalveolar lavage fluid from granulocytopenic, 
      cytokine-treated mice. In conclusion, IL-1 beta and TNF alpha treatment exhibited 
      a synergistic protective effect from pulmonary P. aeruginosa challenge in 
      granulocytopenic hosts, probably due to enhancement of nonspecific antibacterial 
      mechanisms.
FAU - Amura, C R
AU  - Amura CR
AD  - Laboratorio de Bacteriologia, Facultad de Medicina, Universidad de Buenos Aires, 
      Argentina.
FAU - Fontan, P A
AU  - Fontan PA
FAU - Sanjuan, N
AU  - Sanjuan N
FAU - Sordelli, D O
AU  - Sordelli DO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Immunol Immunopathol
JT  - Clinical immunology and immunopathology
JID - 0356637
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Agranulocytosis/microbiology/physiopathology
MH  - Animals
MH  - Cytokines/therapeutic use
MH  - Disease Models, Animal
MH  - Female
MH  - Interleukin-1/*therapeutic use
MH  - Lung Diseases/microbiology/physiopathology/*therapy
MH  - Male
MH  - Mice
MH  - Pneumonia/microbiology
MH  - Pseudomonas Infections
MH  - *Pseudomonas aeruginosa
MH  - Recombinant Proteins/therapeutic use
MH  - Tumor Necrosis Factor-alpha/*therapeutic use
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - S0090122984711962 [pii]
AID - 10.1006/clin.1994.1196 [doi]
PST - ppublish
SO  - Clin Immunol Immunopathol. 1994 Nov;73(2):261-6. doi: 10.1006/clin.1994.1196.